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spi spitz [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35253, updated on 2-Nov-2024

Summary

Official Symbol
spiprovided by FlyBase
Official Full Name
spitzprovided by FlyBase
Primary source
FLYBASE:FBgn0005672
Locus tag
Dmel_CG10334
See related
AllianceGenome:FB:FBgn0005672
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.158; CG10334; CT29014; Dmel\CG10334; EP(2)2378; l(2)01068; l(2)37Fa; l(2)s3547; s-spi; s.spi; Spi; Spitz; sSpi
Summary
Enables epidermal growth factor receptor binding activity; receptor ligand activity; and transmembrane receptor protein tyrosine kinase activator activity. Involved in several processes, including behavioral response to ethanol; embryonic morphogenesis; and nervous system development. Located in endoplasmic reticulum; extracellular space; and membrane. Is expressed in several structures, including brain; gut section; head epidermis primordium; mushroom body; and sensory nervous system primordium. Used to study alcohol use disorder and intestinal cancer. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See spi in Genome Data Viewer
Location:
37F2-37F2; 2-54 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19567900..19577315, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19567900..19577315, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-2a-2 stem loop Neighboring gene mir-2a-1 stem loop Neighboring gene mir-2b-2 stem loop Neighboring gene msb1l Neighboring gene Phosphomevalonate kinase Neighboring gene hakai

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables epidermal growth factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables epidermal growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
enables receptor ligand activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in behavioral response to ethanol IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in determination of genital disc primordium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dorsal closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ectodermal cell fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial cell proliferation involved in Malpighian tubule morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oenocyte development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in oenocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in olfactory learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ommatidial rotation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peripheral nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in photoreceptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in photoreceptor cell fate determination IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spiracle morphogenesis, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stem cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stomatogastric nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
spitz
Names
CG10334-PA
CG10334-PB
CG10334-PE
CG10334-PF
CG10334-PG
epidermal growth factor protein
spi-PA
spi-PB
spi-PE
spi-PF
spi-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    19567900..19577315 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057561.6NP_476909.2  spitz, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476909.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q01083, Q8SXE0, Q9VIT4
    UniProtKB/TrEMBL
    A4V0W1
    Related
    FBpp0080808
  2. NM_134291.5NP_599118.2  spitz, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_599118.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q01083, Q8SXE0, Q9VIT4
    UniProtKB/TrEMBL
    A4V0W1
    Related
    FBpp0080809
  3. NM_001032110.2NP_001027281.1  spitz, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027281.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q01083, Q8SXE0, Q9VIT4
    UniProtKB/TrEMBL
    A4V0W1
  4. NM_134292.3NP_599119.2  spitz, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_599119.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q01083, Q8SXE0, Q9VIT4
    UniProtKB/TrEMBL
    A4V0W1
    Related
    FBpp0080811
  5. NM_134293.3NP_599120.2  spitz, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_599120.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q01083, Q8SXE0, Q9VIT4
    UniProtKB/TrEMBL
    A4V0W1
    Related
    FBpp0080810