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CG10137 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35241, updated on 2-Nov-2024

Summary

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Official Symbol
CG10137provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0032800
Locus tag
Dmel_CG10137
See related
AllianceGenome:FB:FBgn0032800
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG10137
Summary
Enables microtubule binding activity. Involved in centriole elongation; motile cilium assembly; and non-motile cilium assembly. Located in centriole and ciliary basal body. Human ortholog(s) of this gene implicated in Joubert syndrome 25 and autosomal recessive intellectual developmental disorder 77. Orthologous to human CEP104 (centrosomal protein 104). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See CG10137 in Genome Data Viewer
Location:
37E5-37F1; 2-54 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19526686..19532985)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19526686..19532985)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43363 Neighboring gene uncharacterized protein Neighboring gene Dolichyl-phosphate mannosyltransferase subunit 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45455

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cep104 is a component of the centriole distal tip complex that regulates centriole growth and contributes to Drosophila spermiogenesis. Ryniawec JM, et al. Curr Biol, 2023 Oct 9. PMID 37729913, Free PMC Article
  2. Rapid Low-Cost Assembly of the Drosophila melanogaster Reference Genome Using Low-Coverage, Long-Read Sequencing. Solares EA, et al. G3 (Bethesda), 2018 Oct 3. PMID 30018084, Free PMC Article
  3. A phylogenetic profiling approach identifies novel ciliogenesis genes in Drosophila and C. elegans. Dobbelaere J, et al. EMBO J, 2023 Aug 15. PMID 37317646, Free PMC Article
  4. Deficiency screening for genomic regions with effects on environmental sensitivity of the sensory bristles of Drosophila melanogaster. Takahashi KH, et al. Evolution, 2012 Sep. PMID 22946809
  5. An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination. Kanca O, et al. Elife, 2022 Jun 20. PMID 35723254, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in centriole elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG10137-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    19526686..19532985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136137.3 → NP_609981.1  uncharacterized protein Dmel_CG10137 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609981.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TX9, Q9VIU5
    Related
    FBpp0080789
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VIU5 Q9VIU5

Gene LinkOut

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