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Dus4 Dihydrouridine synthase 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35179, updated on 18-Sep-2024

Summary

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Official Symbol
Dus4provided by FlyBase
Official Full Name
Dihydrouridine synthase 4provided by FlyBase
Primary source
FLYBASE:FBgn0032750
Locus tag
Dmel_CG10495
See related
AllianceGenome:FB:FBgn0032750
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.200; CG10495; Dmel\CG10495
Summary
Predicted to enable tRNA dihydrouridine synthase activity. Predicted to be involved in tRNA processing. Is expressed in organism. Orthologous to human DUS4L (dihydrouridine synthase 4 like). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Dus4 in Genome Data Viewer
Location:
37B13-37B13; 2-54 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19063295..19064726)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19063295..19064726)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene PH domain leucine-rich repeat protein phosphatase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular evolution of dihydrouridine synthases. Kasprzak JM, et al. BMC Bioinformatics, 2012 Jun 28. PMID 22741570, Free PMC Article
  2. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573, Free PMC Article
  3. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article
  4. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article
  5. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA dihydrouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA dihydrouridine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-dihydrouridine20a synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tRNA-dihydrouridine20b synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dihydrouridine synthase 4
Names
CG10495-PA
Dus4-PA
NP_609939.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    19063295..19064726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136095.3 → NP_609939.1  dihydrouridine synthase 4 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609939.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJ06
    Related
    FBpp0080694
    Conserved Domains (2) summary
    cd02801
    Location:26 → 251
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    pfam01207
    Location:28 → 321
    Dus; Dihydrouridine synthase (Dus)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VJ06 Q9VJ06

Gene LinkOut

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