U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Bhmt Betaine-homocysteine S-methyltransferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35153, updated on 28-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
Bhmtprovided by FlyBase
Official Full Name
Betaine-homocysteine S-methyltransferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0032727
Locus tag
Dmel_CG10623
See related
AllianceGenome:FB:FBgn0032727
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10623; dBHMT; Dmel\CG10623; Met-s
Summary
Predicted to enable S-adenosylmethionine-homocysteine S-methyltransferase activity; S-methylmethionine-homocysteine S-methyltransferase activity; and betaine-homocysteine S-methyltransferase activity. Predicted to be involved in S-methylmethionine cycle and methionine biosynthetic process. Is expressed in yolk nucleus. [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Bhmt in Genome Data Viewer
Location:
37B7-37B7; 2-54 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18955481..18957311, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18955481..18957311, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44741 Neighboring gene Numb-associated kinase Neighboring gene Transport and Golgi organization 6 Neighboring gene L-2-hydroxyglutarate dehydrogenase

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genetic Targeting of dSAMTOR, A Negative dTORC1 Regulator, during Drosophila Aging: A Tissue-Specific Pathology. Katarachia SA, et al. Int J Mol Sci, 2023 Jun 2. PMID 37298625, Free PMC Article
  2. Recognition of age-damaged (R,S)-adenosyl-L-methionine by two methyltransferases in the yeast Saccharomyces cerevisiae. Vinci CR, et al. J Biol Chem, 2007 Mar 23. PMID 17264075
  3. The Transcriptional Corepressor SIN3 Directly Regulates Genes Involved in Methionine Catabolism and Affects Histone Methylation, Linking Epigenetics and Metabolism. Liu M, et al. J Biol Chem, 2017 Feb 3. PMID 28028175, Free PMC Article
  4. Sex-specific effects of cis-regulatory variants in Drosophila melanogaster. Coolon JD, et al. Genetics, 2013 Dec. PMID 24097411, Free PMC Article
  5. Disruption of Methionine Metabolism in Drosophila melanogaster Impacts Histone Methylation and Results in Loss of Viability. Liu M, et al. G3 (Bethesda), 2015 Nov 6. PMID 26546310, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables S-adenosylmethionine-homocysteine S-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables S-methylmethionine-homocysteine S-methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables betaine-homocysteine S-methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in S-methylmethionine cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in methionine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Betaine-homocysteine S-methyltransferase
Names
Bhmt-PA
Bhmt-PB
Bhmt-PC
CG10623-PA
CG10623-PB
CG10623-PC
betaine-homocysteine methyl-transferase
selenocysteine methyltransferase
NP_001286073.1
NP_001286074.1
NP_609921.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    18955481..18957311 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299145.1 → NP_001286074.1  Betaine-homocysteine S-methyltransferase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286074.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0APQ1, A0APQ2, A0APR1, C0MKB3, C0MKB5, Q9VJ31
    Conserved Domains (1) summary
    cl22882
    Location:9 → 322
    S-methyl_trans; Homocysteine S-methyltransferase

  2. NM_136077.2 → NP_609921.1  Betaine-homocysteine S-methyltransferase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609921.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0APQ1, A0APQ2, A0APR1, C0MKB3, C0MKB5, Q9VJ31
    Related
    FBpp0080731
    Conserved Domains (1) summary
    cl22882
    Location:9 → 322
    S-methyl_trans; Homocysteine S-methyltransferase

  3. NM_001299144.1 → NP_001286073.1  Betaine-homocysteine S-methyltransferase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286073.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0APQ1, A0APQ2, A0APR1, C0MKB3, C0MKB5, Q9VJ31
    Conserved Domains (1) summary
    cl22882
    Location:9 → 322
    S-methyl_trans; Homocysteine S-methyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VJ31 Q9VJ31

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools