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ham hamlet [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35135, updated on 2-Nov-2024

Summary

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Official Symbol
hamprovided by FlyBase
Official Full Name
hamletprovided by FlyBase
Primary source
FLYBASE:FBgn0045852
Locus tag
Dmel_CG31753
See related
AllianceGenome:FB:FBgn0045852
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10568; CG15906; CG15907; CG31753; Dmel\CG31753; Ham; HAM_DROME
Summary
Enables DNA-binding transcription factor activity. Involved in several processes, including neuroblast fate commitment; regulation of DNA-templated transcription; and regulation of dendrite development. Located in nucleus. Is expressed in several structures, including embryonic dorsal sensory organ precursor cluster; embryonic lateral sensory organ precursor cluster; embryonic ventral sensory organ precursor cluster group; presumptive embryonic/larval peripheral nervous system; and somatic precursor cell. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1LL and myeloid neoplasm. Orthologous to several human genes including MECOM (MDS1 and EVI1 complex locus). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See ham in Genome Data Viewer
Location:
37A2-37A4; 2-54 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18762874..18792906, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18762874..18792906, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43804 Neighboring gene long non-coding RNA:CR44904 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dendrites of distinct classes of Drosophila sensory neurons show different capacities for homotypic repulsion. Grueber WB, et al. Curr Biol, 2003 Apr 15. PMID 12699617
  2. Nociceptive Biology of Molluscs and Arthropods: Evolutionary Clues About Functions and Mechanisms Potentially Related to Pain. Walters ET. Front Physiol, 2018. PMID 30123137, Free PMC Article
  3. Control of multidendritic neuron differentiation in Drosophila: the role of Collier. Crozatier M, et al. Dev Biol, 2008 Mar 1. PMID 18234173
  4. Exercise and/or Cold Exposure Alters the Gene Expression Profile in the Fat Body and Changes the Heart Function in Drosophila. Huang T, et al. Front Endocrinol (Lausanne), 2022. PMID 35418948, Free PMC Article
  5. The transcription factor odd-paired regulates temporal identity in transit-amplifying neural progenitors via an incoherent feed-forward loop. Abdusselamoglu MD, et al. Elife, 2019 Jul 22. PMID 31329099, Free PMC Article

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of physical and functional interactions between Drosophila homologue of Swc6/p18Hamlet subunit of the SWR1/SRCAP chromatin-remodeling complex with the DNA repair/transcription factor TFIIH
    Title: Physical and functional interactions between Drosophila homologue of Swc6/p18Hamlet subunit of the SWR1/SRCAP chromatin-remodeling complex with the DNA repair/transcription factor TFIIH.
  2. This study demonistrated that Ham modifies cellular responses to these iteratively used Notch signals in a context-dependent manner, and controls odorant receptor gene choice and ORN axon targeting specificity.
    Title: Chromatin modification of Notch targets in olfactory receptor neuron diversification.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c18791805-18791361 mobile_element_type = transposon:INE-1{}3935

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K9 methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in dendrite morphogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuroblast fate commitment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of dendrite development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
hamlet
Names
CG31753-PB
CG31753-PD
CG31753-PE
CG31753-PG
CG31753-PH
ham-PB
ham-PD
ham-PE
ham-PG
ham-PH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    18762874..18792906 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273614.1 → NP_001260543.1  hamlet, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260543.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8I7Z8, Q9VJ50, Q9VJ52
    UniProtKB/TrEMBL
    M9PBD2
    Conserved Domains (5) summary
    COG5048
    Location:817 → 910
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:819 → 839
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:817 → 839
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:831 → 855
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:310 → 388
    zf-C2H2_8; C2H2-type zinc ribbon

  2. NM_001259152.1 → NP_001246081.1  hamlet, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246081.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8I7Z8, Q9VJ50, Q9VJ52
    UniProtKB/TrEMBL
    M9PBD2
    Conserved Domains (5) summary
    COG5048
    Location:817 → 910
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:819 → 839
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:817 → 839
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:831 → 855
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:310 → 388
    zf-C2H2_8; C2H2-type zinc ribbon

  3. NM_001273616.1 → NP_001260545.2  hamlet, isoform H [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDM9
    Conserved Domains (8) summary
    PTZ00121
    Location:597 → 684
    PTZ00121; MAEBL; Provisional
    COG5048
    Location:891 → 984
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:347 → 435
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:893 → 913
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl40432
    Location:131 → 209
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
    pfam00096
    Location:891 → 913
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:905 → 929
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:359 → 401
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  4. NM_165262.3 → NP_724130.4  hamlet, isoform G [Drosophila melanogaster]

    Status: REVIEWED

    Conserved Domains (8) summary
    PTZ00121
    Location:641 → 728
    PTZ00121; MAEBL; Provisional
    COG5048
    Location:935 → 1028
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:391 → 479
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:937 → 957
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd19201
    Location:131 → 253
    PR-SET_ZFPM; PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins
    pfam00096
    Location:935 → 957
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:949 → 973
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:403 → 445
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

  5. NM_001273615.1 → NP_001260544.1  hamlet, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260544.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PD45
    Conserved Domains (4) summary
    COG5048
    Location:460 → 553
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:462 → 482
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:460 → 482
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:474 → 498
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PBD2 M9PBD2
M9PD45 M9PD45
M9PDM9 M9PDM9
Q8I7Z8.1 Q8I7Z8

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