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bsf bicoid stability factor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35100, updated on 11-Sep-2024

Summary

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Official Symbol
bsfprovided by FlyBase
Official Full Name
bicoid stability factorprovided by FlyBase
Primary source
FLYBASE:FBgn0284256
Locus tag
Dmel_CG10302
See related
AllianceGenome:FB:FBgn0284256
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Bsf; BSF; CG10302; Dmel\CG10302; dmlrpprc1; DmLrpprc1; DmLRPPRC1; l(2)SH1181; l(2)SH2 1181
Summary
Enables mRNA 3'-UTR binding activity. Involved in several processes, including mRNA processing; positive regulation of oxidative phosphorylation; and regulation of mitochondrial gene expression. Located in H zone; Z disc; and mitochondrion. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in French Canadian Leigh disease and Leigh disease. Orthologous to human LRPPRC (leucine rich pentatricopeptide repeat containing). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See bsf in Genome Data Viewer
Location:
36F5-36F5; 2-53 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18449517..18454587, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18449517..18454587, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Ribosomal protein S26 Neighboring gene nucampholin Neighboring gene let-7 Complex Neighboring gene Nuclear transport factor-2-related Neighboring gene mir-100 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Stable Isotope Labeling of Amino Acids in Flies (SILAF) Reveals Differential Phosphorylation of Mitochondrial Proteins Upon Loss of OXPHOS Subunits. Rosenberger FA, et al. Mol Cell Proteomics, 2021. PMID 33640490, Free PMC Article
  2. BSF binds specifically to the bicoid mRNA 3' untranslated region and contributes to stabilization of bicoid mRNA. Mancebo R, et al. Mol Cell Biol, 2001 May. PMID 11313472, Free PMC Article
  3. CGG repeat expansion in NOTCH2NLC causes mitochondrial dysfunction and progressive neurodegeneration in Drosophila model. Yu J, et al. Proc Natl Acad Sci U S A, 2022 Oct 11. PMID 36191230, Free PMC Article
  4. Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA in vivo. Pajak A, et al. PLoS Genet, 2019 Jul. PMID 31365523, Free PMC Article
  5. The PPR domain of mitochondrial RNA polymerase is an exoribonuclease required for mtDNA replication in Drosophila melanogaster. Liu Y, et al. Nat Cell Biol, 2022 May. PMID 35449456

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Although the C region of the osk 3' UTR is required for the noncoding function, BSF binding does not appear to be essential for that function.
    Title: RNA sequences required for the noncoding function of oskar RNA also mediate regulation of Oskar protein expression by Bicoid Stability Factor.
  2. Epistasis studies showed that Mbl silencing was sufficient to induce a subcellular redistribution of TBPH and BSF proteins in the muscle, which mimicked the effect of i(CTG)480 expression.
    Title: Muscleblind, BSF and TBPH are mislocalized in the muscle sarcomere of a Drosophila myotonic dystrophy model.
  3. it reports of a novel function of BSF in flies and demonstrates that it has an important intra-mitochondrial role, which is essential for maintaining mtDNA gene expression and oxidative phosphorylation.
    Title: The bicoid stability factor controls polyadenylation and expression of specific mitochondrial mRNAs in Drosophila melanogaster.
  4. activation of the zygotic genome starts from intronless genes sharing a common cis-element. This cis-element interacts with a single protein, Bicoid stability factor, & acts as potent enhancer capable of timing activity of an exogenous transactivator.
    Title: Unmasking activation of the zygotic genome using chromosomal deletions in the Drosophila embryo.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial mRNA polyadenylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polycistronic mRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of oxidative phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitochondrial gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitochondrial mRNA stability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitochondrial transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in H zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IC
Inferred by Curator
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
bicoid stability factor
Names
CG10302-PA
bicoid stabilization factor
bsf-PA
lethal (2) SH1181

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    18449517..18454587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078872.5 → NP_523596.2  bicoid stability factor [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523596.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95NR4, Q9VJ86
    Related
    FBpp0080637
    Conserved Domains (4) summary
    sd00004
    Location:177 → 204
    PPR; PPR repeat [structural motif]
    pfam12854
    Location:169 → 202
    PPR_1; PPR repeat
    pfam13041
    Location:173 → 222
    PPR_2; PPR repeat family
    cl00219
    Location:456 → 543
    Pterin_binding; Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95NR4 Q95NR4
Q9VJ86 Q9VJ86

Gene LinkOut

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