Oli Olig family [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Oliprovided by FlyBase
Official Full Name: Olig familyprovided by FlyBase
Primary source: FLYBASE:FBgn0032651
Locus tag: Dmel_CG5545
See related: AllianceGenome:FB:FBgn0032651
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: bHLHb23; CG5545; Dmel\CG5545; Doli; oli; Olig
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in motor neuron axon guidance. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; extended germ band embryo; lateral cord neurons; somatic precursor cell; and ventral midline of embryo. Orthologous to human BHLHE22 (basic helix-loop-helix family member e22) and BHLHE23 (basic helix-loop-helix family member e23). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 36D1-36D1; 2-53 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (17589184..17591267)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (17589184..17591267)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In the embryonic nervous system, Oli is primarily expressed in postmitotic progeny, and in particular, in distinct ventral motoneuron subtypes. oli mediates axonal trajectory selection of these motoneurons within the ventral nerve cord.
Title: Regulation of locomotion and motoneuron trajectory selection and targeting by the Drosophila homolog of Olig family transcription factors.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: olig family

Names: CG5545-PA; CG5545-PB; CG5545-PC; CG5545-PD; Oli-PA; Oli-PB; Oli-PC; Oli-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

17589184..17591267

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001299088.1 → NP_001286017.1 olig family, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286017.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VJC1

Conserved Domains (1) summary

cd18954
Location:129 → 198

bHLH_TS_bHLHe22_bHLHb5; basic helix-loop-helix (bHLH) domain found in Class E basic helix-loop-helix protein 22 (bHLHe22) and similar proteins
NM_078868.3 → NP_523592.1 olig family, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523592.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VJC1

Related

FBpp0080539

Conserved Domains (1) summary

cd18954
Location:129 → 198

bHLH_TS_bHLHe22_bHLHb5; basic helix-loop-helix (bHLH) domain found in Class E basic helix-loop-helix protein 22 (bHLHe22) and similar proteins
NM_001201901.2 → NP_001188830.1 olig family, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188830.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VJC1

Conserved Domains (1) summary

cd18954
Location:129 → 198

bHLH_TS_bHLHe22_bHLHb5; basic helix-loop-helix (bHLH) domain found in Class E basic helix-loop-helix protein 22 (bHLHe22) and similar proteins
NM_001201902.1 → NP_001188831.1 olig family, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188831.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VJC1

Conserved Domains (1) summary

cd18954
Location:129 → 198

bHLH_TS_bHLHe22_bHLHb5; basic helix-loop-helix (bHLH) domain found in Class E basic helix-loop-helix protein 22 (bHLHe22) and similar proteins