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Rnmt RNA guanine-7 methyltransferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34877, updated on 2-Nov-2024

Summary

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Official Symbol
Rnmtprovided by FlyBase
Official Full Name
RNA guanine-7 methyltransferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0286027
Locus tag
Dmel_CG3688
See related
AllianceGenome:FB:FBgn0286027
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BG:DS00929.5; br9; C2; CG3688; Dmel\CG3688; l(2)10408; l(2)35Bd; l(2)br9; RNA-guanine-7-methyltransferase
Summary
Predicted to enable RNA binding activity and mRNA 5'-cap (guanine-N7-)-methyltransferase activity. Predicted to be involved in 7-methylguanosine mRNA capping. Predicted to be active in nucleus. Is expressed in gonad and larval brain. Orthologous to human RNMT (RNA guanine-7 methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See Rnmt in Genome Data Viewer
Location:
35B8-35B8; 2-50 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15009939..15011764)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15009939..15011764)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Dynactin 5, p25 subunit Neighboring gene Ankrd49 Neighboring gene Negative Cofactor 2beta Neighboring gene long non-coding RNA:CR43856 Neighboring gene tRNA-histidine guanylyltransferase Neighboring gene metabotropic GABA-B receptor subtype 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes. Pillutla RC, et al. J Biol Chem, 1998 Aug 21. PMID 9705270
  2. Genetic and phenotypic analysis of the genes of the elbow-no-ocelli region of chromosome 2L of Drosophila melanogaster. Davis T, et al. Hereditas, 1997. PMID 9175495
  3. The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. III. Hypomorphic and hypermorphic mutations affecting the expression of hairless. Ashburner M. Genetics, 1982 Jul-Aug. PMID 6816670, Free PMC Article
  4. Genetic and cytogenetic analysis of the Adh region in Drosophila melanogaster. O'Donnell J, et al. Genetics, 1977 Jul. PMID 408228, Free PMC Article
  5. The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development. Furukawa T, et al. Cell, 1992 Jun 26. PMID 1617729

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in 7-methylguanosine mRNA capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 7-methylguanosine mRNA capping IEA
Inferred from Electronic Annotation
more info
  
involved_in 7-methylguanosine mRNA capping ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
RNA guanine-7 methyltransferase
Names
CG3688-PA
RNA (guanine-7-)methyltransferase
Rnmt-PA
lethal (2) 35Bd
lethal 9 in the black-reduced region
lethal group C2
NP_523568.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    15009939..15011764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078844.4 → NP_523568.2  RNA guanine-7 methyltransferase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523568.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9N6X4, Q9VJQ4
    Related
    FBpp0080257
    Conserved Domains (1) summary
    pfam03291
    Location:72 → 411
    Pox_MCEL; mRNA capping enzyme
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VJQ4.2 Q9VJQ4

Gene LinkOut

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