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NC2beta Negative Cofactor 2beta [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34875, updated on 28-Oct-2024

Summary

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Official Symbol
NC2betaprovided by FlyBase
Official Full Name
Negative Cofactor 2betaprovided by FlyBase
Primary source
FLYBASE:FBgn0028926
Locus tag
Dmel_CG4185
See related
AllianceGenome:FB:FBgn0028926
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BG:DS00929.3; CG4185; dDr1; Dmel\CG4185; dNC2; dNC2beta; Dr1; NC2 beta; Nc2b
Summary
Enables DNA-binding transcription factor binding activity and core promoter sequence-specific DNA binding activity. Involved in chromatin remodeling; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of ATAC complex. Is expressed in several structures, including embryonic dorsal epidermis; embryonic epipharynx; embryonic head epidermis; embryonic hypopharynx; and ganglia. Orthologous to human DR1 (down-regulator of transcription 1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
all
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Genomic context

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See NC2beta in Genome Data Viewer
Location:
35B8-35B8; 2-50 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15007813..15008538)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15007813..15008538)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene moladietz Neighboring gene Dynactin 5, p25 subunit Neighboring gene Ankrd49 Neighboring gene long non-coding RNA:CR43856 Neighboring gene tRNA-histidine guanylyltransferase Neighboring gene RNA guanine-7 methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A basal transcription factor that activates or represses transcription. Willy PJ, et al. Science, 2000 Nov 3. PMID 11062130
  2. ATAC is a double histone acetyltransferase complex that stimulates nucleosome sliding. Suganuma T, et al. Nat Struct Mol Biol, 2008 Apr. PMID 18327268
  3. A metazoan ATAC acetyltransferase subunit that regulates mitogen-activated protein kinase signaling is related to an ancient molybdopterin synthase component. Suganuma T, et al. Mol Cell Proteomics, 2012 May. PMID 22345504, Free PMC Article
  4. The ATAC acetyltransferase complex coordinates MAP kinases to regulate JNK target genes. Suganuma T, et al. Cell, 2010 Sep 3. PMID 20813260
  5. The Drosophila Duox maturation factor is a key component of a positive feedback loop that sustains regeneration signaling. Khan SJ, et al. PLoS Genet, 2017 Jul. PMID 28753614, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables TBP-class protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables general transcription initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of ATAC complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ATAC complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of negative cofactor 2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of negative cofactor 2 complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
negative cofactor 2beta
Names
CG4185-PA
NC2beta-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    15007813..15008538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135892.4 → NP_609736.1  negative cofactor 2beta [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609736.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q2XYD4, Q9NKA2, Q9VJQ5
    Related
    FBpp0080256
    Conserved Domains (1) summary
    cl23735
    Location:15 → 135
    H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VJQ5.1 Q9VJQ5

Gene LinkOut

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