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Ance Angiotensin converting enzyme [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34805, updated on 18-Sep-2024

Summary

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Official Symbol
Anceprovided by FlyBase
Official Full Name
Angiotensin converting enzymeprovided by FlyBase
Primary source
FLYBASE:FBgn0012037
Locus tag
Dmel_CG8827
See related
AllianceGenome:FB:FBgn0012037
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ACE; ance; AnCE; ANCE; anon-EST:fe3D10; BG:DS08220.3; CG8827; Dmel\CG8827; race; Race; RACE
Summary
Enables metallopeptidase activity and peptidyl-dipeptidase activity. Involved in several processes, including peptide hormone processing; response to symbiotic bacterium; and spermatid development. Located in extracellular space. Is expressed in several structures, including ectoderm anlage; embryonic/larval midgut; germ layer; presumptive embryonic/larval system; and stage 5 embryo. Human ortholog(s) of this gene implicated in several diseases, including Coronavirus infectious disease (multiple); artery disease (multiple); autoimmune disease (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting enzyme) and ACE2 (angiotensin converting enzyme 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Ance in Genome Data Viewer
Location:
34E2-34E2; 2-50 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13905645..13909212)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13905645..13909212)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Centaurin gamma 1A Neighboring gene long non-coding RNA:CR44848 Neighboring gene Smg5 nonsense mediated mRNA decay factor Neighboring gene Ance-2 Neighboring gene Acylphosphatase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila melanogaster angiotensin I-converting enzyme expressed in Pichia pastoris resembles the C domain of the mammalian homologue and does not require glycosylation for secretion and enzymic activity. Williams TA, et al. Biochem J, 1996 Aug 15. PMID 8761461, Free PMC Article
  2. Characterisation of putative Drosophila angiotensin converting enzyme cDNA clones. Cornell MJ, et al. Biochem Soc Trans, 1993 Aug. PMID 8224398
  3. Inactivation of a tachykinin-related peptide: identification of four neuropeptide-degrading enzymes in neuronal membranes of insects from four different orders. Isaac RE, et al. Peptides, 2002 Apr. PMID 11897392
  4. Cloning and expression of an evolutionary conserved single-domain angiotensin converting enzyme from Drosophila melanogaster. Cornell MJ, et al. J Biol Chem, 1995 Jun 9. PMID 7775412
  5. Crystal structure of Drosophila angiotensin I-converting enzyme bound to captopril and lisinopril. Kim HM, et al. FEBS Lett, 2003 Mar 13. PMID 12633854

See all (162) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data report the crystal structures of human testis ACE (tACE) and a homologue of ACE, known as AnCE, from Drosophila melanogaster in complex with a selenium analogue of captopril.
    Title: Structural characterization of angiotensin I-converting enzyme in complex with a selenium analogue of captopril.
  2. ANCE, which shares many enzymatic properties with mammalian ACE, is also a product of the male accessory gland of D. melanogaster.
    Title: Male accessory glands of Drosophila melanogaster make a secreted angiotensin I-converting enzyme (ANCE), suggesting a role for the peptide-processing enzyme in seminal fluid.
  3. Ance is required for spermatid differentiation.
    Title: The drosophila angiotensin-converting enzyme homologue Ance is required for spermiogenesis.
  4. ance may be required for the processing of a developmental peptide hormone or may function in concert with other peptidases to provide amino acids for the synthesis of adult proteins
    Title: Ance, a Drosophila angiotensin-converting enzyme homologue, is expressed in imaginal cells during metamorphosis and is regulated by the steroid, 20-hydroxyecdysone.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metallopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-dipeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidyl-dipeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in metamorphosis IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in peptide hormone processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in response to symbiotic bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in sexual reproduction IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
angiotensin converting enzyme
Names
Ance-PA
Ance-PB
Ance-PC
CG8827-PA
CG8827-PB
CG8827-PC
angiotensin I-converting enzyme
angiotensin-converting enzyme
anon-fast-evolving-3D10
race
related to angiotensin converting enzyme
NP_001285915.1
NP_477046.1
NP_723852.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    13905645..13909212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057698.5 → NP_477046.1  angiotensin converting enzyme, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477046.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V0P3, Q10714, Q27572, Q9NKE4, Q9TX66, Q9VJV3
    UniProtKB/TrEMBL
    X2J8C3
    Related
    FBpp0080129
    Conserved Domains (1) summary
    pfam01401
    Location:19 → 606
    Peptidase_M2; Angiotensin-converting enzyme

  2. NM_001298986.1 → NP_001285915.1  angiotensin converting enzyme, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285915.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V0P3, Q10714, Q27572, Q9NKE4, Q9TX66, Q9VJV3
    UniProtKB/TrEMBL
    X2J8C3
    Conserved Domains (1) summary
    pfam01401
    Location:19 → 606
    Peptidase_M2; Angiotensin-converting enzyme

  3. NM_165070.3 → NP_723852.1  angiotensin converting enzyme, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723852.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V0P3, Q10714, Q27572, Q9NKE4, Q9TX66, Q9VJV3
    UniProtKB/TrEMBL
    X2J8C3
    Related
    FBpp0080130
    Conserved Domains (1) summary
    pfam01401
    Location:19 → 606
    Peptidase_M2; Angiotensin-converting enzyme
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q10714.3 Q10714
X2J8C3 X2J8C3

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