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Smg5 Smg5 nonsense mediated mRNA decay factor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34804, updated on 18-Sep-2024

Summary

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Official Symbol
Smg5provided by FlyBase
Official Full Name
Smg5 nonsense mediated mRNA decay factorprovided by FlyBase
Primary source
FLYBASE:FBgn0019890
Locus tag
Dmel_CG8954
See related
AllianceGenome:FB:FBgn0019890
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-34Ea; BG:DS08220.2; br31; CG8954; Dmel\CG8954; dSMG5; l(2)34Eb; l(2)br31; l34Eb; smg5; SMG5; Smg5 nonsense RNA decay factor
Summary
Predicted to enable telomerase RNA binding activity and telomeric DNA binding activity. Involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Predicted to be part of telomerase holoenzyme complex. Is expressed in several structures, including adult head; embryonic brain; embryonic/larval nervous system; extended germ band embryo; and germ layer. Orthologous to human SMG5 (SMG5 nonsense mediated mRNA decay factor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Smg5 in Genome Data Viewer
Location:
34E2-34E2; 2-50 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13898828..13904661, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13898828..13904661, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Centaurin gamma 1A Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44848 Neighboring gene Angiotensin converting enzyme Neighboring gene Ance-2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The drosophila angiotensin-converting enzyme homologue Ance is required for spermiogenesis. Hurst D, et al. Dev Biol, 2003 Feb 15. PMID 12591244
  2. SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan. Huntzinger E, et al. RNA, 2008 Dec. PMID 18974281, Free PMC Article
  3. Race: a Drosophila homologue of the angiotensin converting enzyme. Tatei K, et al. Mech Dev, 1995 Jun. PMID 7547464
  4. Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. Glavan F, et al. EMBO J, 2006 Nov 1. PMID 17053788, Free PMC Article
  5. Tau-induced deficits in nonsense-mediated mRNA decay contribute to neurodegeneration. Zuniga G, et al. Alzheimers Dement, 2023 Feb. PMID 35416419, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results provide evidence that Smg5 is essential for nonsense-mediated messenger RNA activity.
    Title: Multiple Nonsense-Mediated mRNA Processes Require Smg5 in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables telomerase RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
NOT involved_in miRNA-mediated post-transcriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of telomerase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Smg5 nonsense mediated mRNA decay factor
Names
CG8954-PA
CG8954-PB
CG8954-PC
Smg5-PA
Smg5-PB
Smg5-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    13898828..13904661 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165069.2 → NP_723851.1  Smg5 nonsense mediated mRNA decay factor, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723851.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V414
    Related
    FBpp0080139
    Conserved Domains (3) summary
    cd09884
    Location:1012 → 1173
    PIN_Smg5; PIN domain of human telomerase-binding protein EST1, Smg5, and other similar eukaryotic homologs
    pfam10373
    Location:240 → 478
    EST1_DNA_bind; Est1 DNA/RNA binding domain
    pfam10374
    Location:99 → 222
    EST1; Telomerase activating protein Est1

  2. NM_001298985.1 → NP_001285914.1  Smg5 nonsense mediated mRNA decay factor, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285914.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V414
    Conserved Domains (3) summary
    cd09884
    Location:1012 → 1173
    PIN_Smg5; PIN domain of human telomerase-binding protein EST1, Smg5, and other similar eukaryotic homologs
    pfam10373
    Location:240 → 478
    EST1_DNA_bind; Est1 DNA/RNA binding domain
    pfam10374
    Location:99 → 222
    EST1; Telomerase activating protein Est1

  3. NM_135841.5 → NP_609685.1  Smg5 nonsense mediated mRNA decay factor, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609685.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V414
    Related
    FBpp0080138
    Conserved Domains (3) summary
    cd09884
    Location:1012 → 1173
    PIN_Smg5; PIN domain of human telomerase-binding protein EST1, Smg5, and other similar eukaryotic homologs
    pfam10373
    Location:240 → 478
    EST1_DNA_bind; Est1 DNA/RNA binding domain
    pfam10374
    Location:99 → 222
    EST1; Telomerase activating protein Est1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T080 Q8T080
Q95TL1 Q95TL1
Q9V414 Q9V414

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