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Arpc1 Actin-related protein 2/3 complex, subunit 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34793, updated on 10-May-2024

Summary

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Official Symbol
Arpc1provided by FlyBase
Official Full Name
Actin-related protein 2/3 complex, subunit 1provided by FlyBase
Primary source
FLYBASE:FBgn0001961
Locus tag
Dmel_CG8978
See related
AllianceGenome:FB:FBgn0001961
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
34Dd; ARC-P41; arc41; Arc41; ArcP41; arpc1; arpC1; ArpC1; ARPC1; ARPC1/p41; BG:DS00941.7; br32; CG8978; D-sop2; Dmel\CG8978; Dsop2; DSop2; l(2)34Dd; l(2)br32; l(2)Sop2; p41; p42; sop; sop2; Sop2; sop2/arc41; Spo2
Summary
Predicted to enable actin filament binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in several processes, including actin filament reorganization involved in cell cycle; axon development; and sensory organ development. Located in cytosol and nuclear lamina. Colocalizes with nuclear envelope. Is expressed in several structures, including anterior endoderm; embryonic/larval muscle system; extended germ band embryo; ring canal; and visceral muscle primordium. Human ortholog(s) of this gene implicated in gastritis; immunodeficiency 71; myelodysplastic syndrome; and pancreatic cancer. Orthologous to human ARPC1A (actin related protein 2/3 complex subunit 1A) and ARPC1B (actin related protein 2/3 complex subunit 1B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Arpc1 in Genome Data Viewer
Location:
34D1-34D1; 2-49 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13827941..13829741, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13827941..13829741, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene black Neighboring gene DNA polymerase gamma subunit 1 Neighboring gene Origin recognition complex subunit 5 Neighboring gene DNA polymerase gamma subunit 2 Neighboring gene Glutamyl-tRNA amidotransferase, subunit C Neighboring gene RNA polymerase II subunit C Neighboring gene mitochondrial ribosomal protein S23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. HtsRC-Mediated Accumulation of F-Actin Regulates Ring Canal Size During Drosophila melanogaster Oogenesis. Gerdes JA, et al. Genetics, 2020 Nov. PMID 32883702, Free PMC Article
  2. F-BAR domain protein Syndapin regulates actomyosin dynamics during apical cap remodeling in syncytial Drosophila embryos. Sherlekar A, et al. J Cell Sci, 2020 May 26. PMID 32327556
  3. Transient localization of the Arp2/3 complex initiates neuronal dendrite branching in vivo. Stürner T, et al. Development, 2019 Apr 4. PMID 30910826
  4. Active diffusion and advection in Drosophila oocytes result from the interplay of actin and microtubules. Drechsler M, et al. Nat Commun, 2017 Nov 15. PMID 29142223, Free PMC Article
  5. Actin dynamics: the arp2/3 complex branches out. Kiehart DP, et al. Curr Biol, 2002 Aug 20. PMID 12194837

See all (122) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Arp2/3 complex-mediated actin nucleation IEA
Inferred from Electronic Annotation
more info
  
involved_in Arp2/3 complex-mediated actin nucleation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axonal fasciculation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in axonogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell adhesion mediated by integrin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chaeta morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear envelope budding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pseudocleavage involved in syncytial blastoderm formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Arp2/3 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Arp2/3 protein complex IEA
Inferred from Electronic Annotation
more info
  
part_of Arp2/3 protein complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of Arp2/3 protein complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of Arp2/3 protein complex TAS
Traceable Author Statement
more info
 PubMed 
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear lamina IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Actin-related protein 2/3 complex, subunit 1
Names
Arpc1-PA
Arpc1-PB
CG8978-PA
CG8978-PB
lethal(2)34Dd
profilin 2
suppressor of
suppressor of profilin 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    13827941..13829741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165063.3 → NP_723845.1  Actin-related protein 2/3 complex, subunit 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723845.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O97182
    Related
    FBpp0080146
    Conserved Domains (3) summary
    COG2319
    Location:3 → 181
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:14 → 53
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:3 → 236
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_057248.5 → NP_476596.1  Actin-related protein 2/3 complex, subunit 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476596.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O97182
    Related
    FBpp0080147
    Conserved Domains (3) summary
    COG2319
    Location:3 → 181
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:14 → 53
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:3 → 236
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O97182 O97182

Gene LinkOut

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