AMIGO2 adhesion molecule with Ig like domain 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: AMIGO2provided by HGNC
Official Full Name: adhesion molecule with Ig like domain 2provided by HGNC
Primary source: HGNC:HGNC:24073
See related: Ensembl:ENSG00000139211 MIM:615690; AllianceGenome:HGNC:24073
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ALI1; DEGA; AMIGO-2
Summary: Predicted to be involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and negative regulation of programmed cell death. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in nucleus and plasma membrane. Predicted to be integral component of membrane. Biomarker of gastric adenocarcinoma. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in gall bladder (RPKM 9.4), urinary bladder (RPKM 8.8) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q13.11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (47075707..47079959, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (47036477..47040734, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (47469490..47473742, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AMIGO2 is a pivotal therapeutic target related to M2 polarization of macrophages in pancreatic ductal adenocarcinoma.
Title: AMIGO2 is a pivotal therapeutic target related to M2 polarization of macrophages in pancreatic ductal adenocarcinoma.
AMIGO2 attenuates innate cisplatin sensitivity by suppression of GSDME-conferred pyroptosis in non-small cell lung cancer.
Title: AMIGO2 attenuates innate cisplatin sensitivity by suppression of GSDME-conferred pyroptosis in non-small cell lung cancer.
Liver Metastasis Formation Is Defined by AMIGO2 Expression via Adhesion to Hepatic Endothelial Cells in Human Gastric and Colorectal Cancer Cells.
Title: Liver Metastasis Formation Is Defined by AMIGO2 Expression via Adhesion to Hepatic Endothelial Cells in Human Gastric and Colorectal Cancer Cells.
The impact of AMIGO2 on prognosis and hepatic metastasis in gastric cancer patients.
Title: The impact of AMIGO2 on prognosis and hepatic metastasis in gastric cancer patients.
AMIGO2 contained in cancer cell-derived extracellular vesicles enhances the adhesion of liver endothelial cells to cancer cells.
Title: AMIGO2 contained in cancer cell-derived extracellular vesicles enhances the adhesion of liver endothelial cells to cancer cells.
In vivo selection of highly metastatic human ovarian cancer sublines reveals role for AMIGO2 in intra-peritoneal metastatic regulation.
Title: In vivo selection of highly metastatic human ovarian cancer sublines reveals role for AMIGO2 in intra-peritoneal metastatic regulation.
AMIGO2 Expression as a Potential Prognostic Biomarker for Gastric Cancer.
Title: AMIGO2 Expression as a Potential Prognostic Biomarker for Gastric Cancer.
Amigo2, which is a member of the Amigo family that shows high species conservation, may be involved in determining liver metastasis by preferential adhesion of the tumour cells to liver endothelial cells.
Title: Amigo2-upregulation in Tumour Cells Facilitates Their Attachment to Liver Endothelial Cells Resulting in Liver Metastases.
this study uncovers mechanisms underlying the therapeutic effects of BETi in melanoma and reveals the AMIGO2-PTK7 axis as a targetable pathway for metastatic melanoma.
Title: Harnessing BET Inhibitor Sensitivity Reveals AMIGO2 as a Melanoma Survival Gene.
AMIGO2 is an important regulator of the PDK1-Akt pathway.
Title: AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-82896 (e-PCR)
- UniSTS:96089

AMIGO2__4296 (e-PCR)
- UniSTS:462728

RH102080 (e-PCR)
- UniSTS:96414

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of programmed cell death	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of synapse assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: amphoterin-induced protein 2

Names: alivin 1; amphoterin induced gene 2; differentially expressed in gastric adenocarcinoma; differentially expressed in gastric adenocarcinomas; transmembrane protein AMIGO2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001143668.1 → NP_001137140.1 amphoterin-induced protein 2 precursor

See identical proteins and their annotated locations for NP_001137140.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) includes an alternate exon in the 5' UTR. The same protein is encoded by transcript variants 1-3.

Source sequence(s)

AB079074, AC004010, BC047595, BC095477

Consensus CDS

CCDS8751.1

UniProtKB/Swiss-Prot

Q4VBP6, Q7Z4A0, Q86SJ2, Q96CN8

UniProtKB/TrEMBL

B3KRK1

Related

ENSP00000406020.1, ENST00000429635.1

Conserved Domains (5) summary

smart00410
Location:298 → 380

IG_like; Immunoglobulin like

COG4886
Location:54 → 240

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:51 → 72

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:94 → 175

LRR_8; Leucine rich repeat

cl15307
Location:228 → 283

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
NM_001370299.1 → NP_001357228.1 amphoterin-induced protein 2 precursor

Status: VALIDATED

Source sequence(s)

AC004010

Consensus CDS

CCDS8751.1

UniProtKB/Swiss-Prot

Q4VBP6, Q7Z4A0, Q86SJ2, Q96CN8

UniProtKB/TrEMBL

B3KRK1

Related

ENSP00000449034.1, ENST00000550413.2

Conserved Domains (5) summary

smart00410
Location:298 → 380

IG_like; Immunoglobulin like

COG4886
Location:54 → 240

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:51 → 72

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:94 → 175

LRR_8; Leucine rich repeat

cl15307
Location:228 → 283

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
NM_181847.4 → NP_862830.1 amphoterin-induced protein 2 precursor

See identical proteins and their annotated locations for NP_862830.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) omits an alternate exon from the 5' UTR. The same protein is encoded by transcript variants 1-3.

Source sequence(s)

AB079074, AC004010, AY454159, BC095477, CN397638

Consensus CDS

CCDS8751.1

UniProtKB/Swiss-Prot

Q4VBP6, Q7Z4A0, Q86SJ2, Q96CN8

UniProtKB/TrEMBL

B3KRK1

Related

ENSP00000266581.4, ENST00000266581.4

Conserved Domains (5) summary

smart00410
Location:298 → 380

IG_like; Immunoglobulin like

COG4886
Location:54 → 240

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:51 → 72

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:94 → 175

LRR_8; Leucine rich repeat

cl15307
Location:228 → 283

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain