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CAH1 Carbonic anhydrase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34786, updated on 10-May-2024

Summary

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Official Symbol
CAH1provided by FlyBase
Official Full Name
Carbonic anhydrase 1provided by FlyBase
Primary source
FLYBASE:FBgn0027844
Locus tag
Dmel_CG7820
See related
AllianceGenome:FB:FBgn0027844
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BG:DS00941.1; CAH; CG7820; Dmel\CG7820; Gh7
Summary
Enables carbonate dehydratase activity. Involved in one-carbon metabolic process. Predicted to be active in cytoplasm. Is expressed in adult fat body; adult head; and embryonic/larval midgut. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 3 and osteopetrosis. Orthologous to several human genes including CA2 (carbonic anhydrase 2); CA5A (carbonic anhydrase 5A); and CA5B (carbonic anhydrase 5B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See CAH1 in Genome Data Viewer
Location:
34D1-34D1; 2-49 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13803626..13809994)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13803626..13809994)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Secretory 71 Neighboring gene Adenosine deaminase, tRNA-specific 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Son of sevenless

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional diversity, conservation, and convergence in the evolution of the alpha-, beta-, and gamma-carbonic anhydrase gene families. Hewett-Emmett D, et al. Mol Phylogenet Evol, 1996 Feb. PMID 8673298
  2. Characterization, bioinformatic analysis and dithiocarbamate inhibition studies of two new α-carbonic anhydrases, CAH1 and CAH2, from the fruit fly Drosophila melanogaster. Syrjänen L, et al. Bioorg Med Chem, 2013 Mar 15. PMID 22989910
  3. Identification of Drosophila Zfh2 as a Mediator of Hypercapnic Immune Regulation by a Genome-Wide RNA Interference Screen. Helenius IT, et al. J Immunol, 2016 Jan 15. PMID 26643480, Free PMC Article
  4. Genes associated with honey bee behavioral maturation affect clock-dependent and -independent aspects of daily rhythmic activity in fruit flies. Fu C, et al. PLoS One, 2012. PMID 22606218, Free PMC Article
  5. Carbonic anhydrases and anion transport in mosquito midgut pH regulation. Linser PJ, et al. J Exp Biol, 2009 Jun. PMID 19448076, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables carbonate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbonate dehydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbonate dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in one-carbon metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in one-carbon metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
carbonic anhydrase 1
Names
CAH1-PA
CG7820-PA
NP_523561.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    13803626..13809994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078837.4 → NP_523561.1  carbonic anhydrase 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523561.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V396
    Related
    FBpp0080116
    Conserved Domains (1) summary
    smart01057
    Location:5 → 263
    Carb_anhydrase; Eukaryotic-type carbonic anhydrase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V396 Q9V396

Gene LinkOut

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