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Sec71 Secretory 71 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34785, updated on 18-Sep-2024

Summary

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Official Symbol
Sec71provided by FlyBase
Official Full Name
Secretory 71provided by FlyBase
Primary source
FLYBASE:FBgn0028538
Locus tag
Dmel_CG7578
See related
AllianceGenome:FB:FBgn0028538
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BG:DS00797.7; BIG1; CG7578; Dmel\CG7578; sec71
Summary
Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in Golgi to plasma membrane protein transport; positive regulation of endocytosis; and positive regulation of neuron remodeling. Located in trans-Golgi network. Is expressed in adult head. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to several human genes including ARFGEF2 (ADP ribosylation factor guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Sec71 in Genome Data Viewer
Location:
34D1-34D1; 2-49 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13793521..13799674)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13793521..13799674)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44847 Neighboring gene Engulfment ABC Transporter in the ovary Neighboring gene uncharacterized protein Neighboring gene Carbonic anhydrase 1 Neighboring gene Adenosine deaminase, tRNA-specific 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sec71 separates Golgi stacks in Drosophila S2 cells. Fujii S, et al. J Cell Sci, 2020 Dec 29. PMID 33262309, Free PMC Article
  2. Phylogenetic analysis of Sec7-domain-containing Arf nucleotide exchangers. Cox R, et al. Mol Biol Cell, 2004 Apr. PMID 14742722, Free PMC Article
  3. Sec71 functions as a GEF for the small GTPase Arf1 to govern dendrite pruning of Drosophila sensory neurons. Wang Y, et al. Development, 2017 May 15. PMID 28420712
  4. The Arf family G protein Arl1 is required for secretory granule biogenesis in Drosophila. Torres IL, et al. J Cell Sci, 2014 May 15. PMID 24610947, Free PMC Article
  5. GBF1 (Gartenzwerg)-dependent secretion is required for Drosophila tubulogenesis. Wang S, et al. J Cell Sci, 2012 Jan 15. PMID 22302994

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ARF protein signal transduction IC
Inferred by Curator
more info
 PubMed 
involved_in Golgi to plasma membrane protein transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron remodeling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of neuron remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
secretory 71
Names
CG7578-PA
Sec71 ortholog
Sec71-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    13793521..13799674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135831.3 → NP_609675.2  secretory 71 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609675.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NKE8, Q9VJW1
    Related
    FBpp0080114
    Conserved Domains (5) summary
    PLN03076
    Location:13 → 1580
    PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
    pfam01369
    Location:582 → 767
    Sec7; Sec7 domain
    pfam09324
    Location:1080 → 1161
    DUF1981; Domain of unknown function (DUF1981)
    pfam12783
    Location:312 → 465
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    pfam16213
    Location:30 → 212
    DCB; Dimerization and cyclophilin-binding domain of Mon2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VJW1 Q9VJW1

Gene LinkOut

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