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Eato Engulfment ABC Transporter in the ovary [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34783, updated on 10-May-2024

Summary

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Official Symbol
Eatoprovided by FlyBase
Official Full Name
Engulfment ABC Transporter in the ovaryprovided by FlyBase
Primary source
FLYBASE:FBgn0028539
Locus tag
Dmel_CG31731
See related
AllianceGenome:FB:FBgn0028539
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BG:DS00797.5; CG31731; CG7491; CG7559; D00797.5; DmCG31731; Dmel\CG31731; DS00797.5
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Located in plasma membrane. Is expressed in adult head; organism; and spermatozoon. Human ortholog(s) of this gene implicated in Alzheimer's disease 9; fundus dystrophy; and retinal degeneration (multiple). Orthologous to several human genes including ABCA10 (ATP binding cassette subfamily A member 10); ABCA4 (ATP binding cassette subfamily A member 4); and ABCA5 (ATP binding cassette subfamily A member 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Eato in Genome Data Viewer
Location:
34D1-34D1; 2-49 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13784084..13790562)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13784084..13790562)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR31845 Neighboring gene p38b MAP kinase Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44847 Neighboring gene uncharacterized protein Neighboring gene Secretory 71

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The ABC Transporter Eato Promotes Cell Clearance in the Drosophila melanogaster Ovary. Santoso CS, et al. G3 (Bethesda), 2018 Mar 2. PMID 29295819, Free PMC Article
  2. Murder on the Ovarian Express: A Tale of Non-Autonomous Cell Death in the Drosophila Ovary. Lebo DPV, et al. Cells, 2021 Jun 10. PMID 34200604, Free PMC Article
  3. Drosophila TAP/p32 is a core histone chaperone that cooperates with NAP-1, NLP, and nucleophosmin in sperm chromatin remodeling during fertilization. Emelyanov AV, et al. Genes Dev, 2014 Sep 15. PMID 25228646, Free PMC Article
  4. Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes. Moulton MJ, et al. Proc Natl Acad Sci U S A, 2021 Dec 28. PMID 34949639, Free PMC Article
  5. Genome annotation assessment in Drosophila melanogaster. Reese MG, et al. Genome Res, 2000 Apr. PMID 10779488, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase-coupled transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in lipid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
engulfment ABC transporter in the ovary
Names
CG31731-PB
CG31731-PC
Eato-PB
Eato-PC
NP_001036360.1
NP_001162974.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    13784084..13790562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042895.3 → NP_001036360.1  engulfment ABC transporter in the ovary, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036360.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E8Q7
    Conserved Domains (4) summary
    TIGR01188
    Location:1262 → 1573
    drrA; daunorubicin resistance ABC transporter ATP-binding subunit
    cd03263
    Location:1255 → 1479
    ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
    COG1131
    Location:460 → 767
    CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
    pfam12698
    Location:937 → 1117
    ABC2_membrane_3; ABC-2 family transporter protein

  2. NM_001169503.2 → NP_001162974.1  engulfment ABC transporter in the ovary, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162974.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JHH7
    Conserved Domains (1) summary
    pfam12698
    Location:209 → 347
    ABC2_membrane_3; ABC-2 family transporter protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JHH7 E1JHH7
Q0E8Q7 Q0E8Q7
Q960V4 Q960V4

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