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Bdp1 B double prime 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34748, updated on 2-Nov-2024

Summary

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Official Symbol
Bdp1provided by FlyBase
Official Full Name
B double prime 1provided by FlyBase
Primary source
FLYBASE:FBgn0032512
Locus tag
Dmel_CG9305
See related
AllianceGenome:FB:FBgn0032512
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9305; Dmel\CG9305
Summary
Enables RNA polymerase III type 3 promoter sequence-specific DNA binding activity. Predicted to be involved in RNA polymerase III preinitiation complex assembly. Part of transcription factor TFIIIB complex. Is expressed in several structures, including anterior endoderm; dorsal pharyngeal muscle primordium; embryonic/larval midgut primordium; larval muscle cell; and mesoderm. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 112. Orthologous to human BDP1 (B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Bdp1 in Genome Data Viewer
Location:
34B8-34B8; 2-48 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13371427..13373890, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13371427..13373890, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Two A-associated protein of 42kDa Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) B22 subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TFIIIB subunit locations on U6 gene promoter DNA mapped by site-specific protein-DNA photo-cross-linking. Kang JJ, et al. FEBS Lett, 2016 May. PMID 27112515
  2. Assembly of SNAPc, Bdp1, and TBP on the U6 snRNA Gene Promoter in Drosophila melanogaster. Kim MK, et al. Mol Cell Biol, 2020 May 28. PMID 32253345, Free PMC Article
  3. Bdp1 interacts with SNAPc bound to a U6, but not U1, snRNA gene promoter element to establish a stable protein-DNA complex. Verma N, et al. FEBS Lett, 2018 Jul. PMID 29932462
  4. Differential utilization of TATA box-binding protein (TBP) and TBP-related factor 1 (TRF1) at different classes of RNA polymerase III promoters. Verma N, et al. J Biol Chem, 2013 Sep 20. PMID 23955442, Free PMC Article
  5. A Genetic Mosaic Screen Reveals Ecdysone-Responsive Genes Regulating Drosophila Oogenesis. Ables ET, et al. G3 (Bethesda), 2016 Aug 9. PMID 27226164, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Assembly of SNAPc, Bdp1, and TBP on the U6 snRNA Gene Promoter in Drosophila melanogaster.
    Title: Assembly of SNAPc, Bdp1, and TBP on the U6 snRNA Gene Promoter in Drosophila melanogaster.
  2. Bdp1 recruitment requires that DmSNAPc be bound to a U6 PSE rather than a U1 PSE. This is consistent with the concept that DmSNAPc adopts different conformations on U6 and U1 PSEs, which lead to the subsequent recruitment of distinct general transcription factors and RNA polymerases for U6 and U1 gene transcription.
    Title: Bdp1 interacts with SNAPc bound to a U6, but not U1, snRNA gene promoter element to establish a stable protein-DNA complex.
  3. Results indicate that a portion of Brf1 is sandwiched between Bdp1 and TBP upstream of the U6 TATA box. Furthermore, Bdp1 traverses the DNA under the N-terminal stirrup of TBP to interact with the DNA (and very likely Brf1) downstream of the TATA sequence.
    Title: TFIIIB subunit locations on U6 gene promoter DNA mapped by site-specific protein-DNA photo-cross-linking.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA polymerase III type 3 promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables TFIIIC-class transcription factor complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase III preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of transcription factor TFIIIB complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIIB complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
B double prime 1
Names
Bdp1-PA
Bdp1-PB
CG9305-PA
CG9305-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    13371427..13373890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298961.1 → NP_001285890.1  B double prime 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285890.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NNW3, X2J875
    Conserved Domains (2) summary
    smart00717
    Location:350 → 395
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam15963
    Location:345 → 419
    Myb_DNA-bind_7; Myb DNA-binding like

  2. NM_135799.3 → NP_609643.2  B double prime 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609643.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NNW3, Q9VJZ3
    Related
    FBpp0080050
    Conserved Domains (2) summary
    smart00717
    Location:350 → 395
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam15963
    Location:345 → 419
    Myb_DNA-bind_7; Myb DNA-binding like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VJZ3 Q9VJZ3
X2J875 X2J875

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