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LANCL3 LanC like family member 3 [ Homo sapiens (human) ]

Gene ID: 347404, updated on 5-Mar-2024

Summary

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Official Symbol
LANCL3provided by HGNC
Official Full Name
LanC like family member 3provided by HGNC
Primary source
HGNC:HGNC:24767
See related
Ensembl:ENSG00000147036 AllianceGenome:HGNC:24767
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in carbohydrate metabolic process. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all
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Genomic context

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Location:
Xp21.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (37571661..37684463)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (36975217..37088020)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (37430914..37543716)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ferritin heavy chain 1 pseudogene 27 Neighboring gene family with sequence similarity 47 member D, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:37544835-37545346 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:37545347-37545856 Neighboring gene H2A.L variant histone 1M, pseudogene Neighboring gene X-linked Kx blood group antigen, Kell and VPS13A binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29518 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29519 Neighboring gene cytochrome b-245 beta chain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Gene expression in proliferating human erythroid cells. Gubin AN, et al. Genomics, 1999 Jul 15. PMID 10409428
  2. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ42925

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in peptide modification IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lanC-like protein 3
Names
LanC lantibiotic synthetase component C-like 3
LanC like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016368.2 RefSeqGene

    Range
    5002..117804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170331.2 → NP_001163802.1  lanC-like protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001163802.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift compared to variant 1. The encoded isoform (2) is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC233297, AI989993, AK124915, BG944288
    Consensus CDS
    CCDS55398.1
    UniProtKB/Swiss-Prot
    A6NHE3, Q6ZV70
    Related
    ENSP00000367882.4, ENST00000378619.4
    Conserved Domains (1) summary
    cd04794
    Location:65 → 414
    euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein

  2. NM_198511.3 → NP_940913.1  lanC-like protein 3 isoform 1

    See identical proteins and their annotated locations for NP_940913.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AC233297, AI989993, AK124915, BG944288
    Consensus CDS
    CCDS14240.1
    UniProtKB/Swiss-Prot
    Q6ZV70
    Related
    ENSP00000367885.3, ENST00000378621.7
    Conserved Domains (1) summary
    cd04794
    Location:65 → 367
    euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    37571661..37684463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543904.3 → XP_011542206.1  lanC-like protein 3 isoform X1

    Conserved Domains (1) summary
    cd04794
    Location:7 → 232
    euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    36975217..37088020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326995.1 → XP_054182970.1  lanC-like protein 3 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZV70.2 GenPept UniProtKB/Swiss-Prot:Q6ZV70

Gene LinkOut

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