Uvrag UV-resistance associated gene [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Uvragprovided by FlyBase
Official Full Name: UV-resistance associated geneprovided by FlyBase
Primary source: FLYBASE:FBgn0032499
Locus tag: Dmel_CG6116
See related: AllianceGenome:FB:FBgn0032499
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6116; Dmel\CG6116; dUVRAG; uvrag; UVRAG; Vps38
Summary: Predicted to enable SNARE binding activity. Involved in several processes, including imaginal disc-derived male genitalia morphogenesis; negative regulation of Notch signaling pathway; and neuron remodeling. Predicted to be active in endosome and lytic vacuole. Is expressed in embryonic/larval garland cell; garland cell primordium; head mesoderm; organism; and trunk mesoderm. Used to study colorectal cancer. Orthologous to human UVRAG (UV radiation resistance associated). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (13286777..13289556)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (13286777..13289556)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

The UVRAG-containing PI3K (III) complex is required for receptor downregulation through endolysosomal degradation and for the establishment of proper cell polarity in the developing wing.
Title: Atg6/UVRAG/Vps34-containing lipid kinase complex is required for receptor downregulation through endolysosomal degradation and epithelial polarity during Drosophila wing development.
UVRAG-mutated heterotaxy patient cells also display highly increased Notch protein levels
Title: UVRAG is required for organ rotation by regulating Notch endocytosis in Drosophila.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in SNARE complex assembly	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in autophagosome maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived male genitalia morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to lysosome	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lytic vacuole	IBA Inferred from Biological aspect of Ancestor more info

Names: CG6116-PA; CG6116-PB; UV radiation resistance associated; UV radiation resistance associated gene; Uvrag-PA; Uvrag-PB; ultraviolet (UV) radiation resistance-associated gene

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