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Edem2 ER degradation enhancer, mannosidase alpha-like 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34714, updated on 11-Sep-2024

Summary

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Official Symbol
Edem2provided by FlyBase
Official Full Name
ER degradation enhancer, mannosidase alpha-like 2provided by FlyBase
Primary source
FLYBASE:FBgn0032480
Locus tag
Dmel_CG5682
See related
AllianceGenome:FB:FBgn0032480
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5682; dEDEM2; Dmel\CG5682; edem2; EDEM2
Summary
Enables unfolded protein binding activity. Involved in endoplasmic reticulum unfolded protein response and ubiquitin-dependent glycoprotein ERAD pathway. Located in endoplasmic reticulum. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human EDEM3 (ER degradation enhancing alpha-mannosidase like protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
34A8-34A9; 2-47 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13192201..13197281)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13192201..13197281)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Alg7 dolichyl-phosphate N-acetylglucosaminephosphotransferase Neighboring gene beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Neighboring gene uncharacterized protein Neighboring gene Radial spoke head protein 1 Neighboring gene uncharacterized protein Neighboring gene Phosphoethanolamine cytidylyltransferase Neighboring gene small nuclear RNA U2 at 34AB a Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role of Drosophila EDEMs in the degradation of the alpha-1-antitrypsin Z variant. Jang BY, et al. Int J Mol Med, 2015 Apr. PMID 25716426, Free PMC Article
  2. Amyloid-β42 clearance and neuroprotection mediated by X-box binding protein 1 signaling decline with aging in the Drosophila brain. Marcora MS, et al. Neurobiol Aging, 2017 Dec. PMID 28917667
  3. A Drosophila metallophosphoesterase mediates deglycosylation of rhodopsin. Cao J, et al. EMBO J, 2011 Jul 29. PMID 21804530, Free PMC Article
  4. Suppression of retinal degeneration in Drosophila by stimulation of ER-associated degradation. Kang MJ, et al. Proc Natl Acad Sci U S A, 2009 Oct 6. PMID 19805114, Free PMC Article
  5. Drosophila oocyte proteome composition covaries with female mating status. McDonough-Goldstein CE, et al. Sci Rep, 2021 Feb 4. PMID 33542461, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
enables unfolded protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum mannose trimming IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum unfolded protein response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endoplasmic reticulum unfolded protein response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mannose trimming involved in glycoprotein ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to endoplasmic reticulum stress IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in ubiquitin-dependent glycoprotein ERAD pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ER degradation enhancer, mannosidase alpha-like 2
Names
CG5682-PA
CG5682-PB
Edem2-PA
Edem2-PB
NP_001260434.1
NP_609611.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    13192201..13197281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135767.2 → NP_609611.1  ER degradation enhancer, mannosidase alpha-like 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609611.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MS36, Q9VK27
    Related
    FBpp0080019
    Conserved Domains (2) summary
    cd02126
    Location:645 → 770
    PA_EDEM3_like; PA_EDEM3_like: protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar ...
    pfam01532
    Location:57 → 494
    Glyco_hydro_47; Glycosyl hydrolase family 47

  2. NM_001273505.1 → NP_001260434.1  ER degradation enhancer, mannosidase alpha-like 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260434.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCV1, Q8MS36
    Conserved Domains (2) summary
    cd02126
    Location:636 → 761
    PA_EDEM3_like; PA_EDEM3_like: protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar ...
    pfam01532
    Location:57 → 494
    Glyco_hydro_47; Glycosyl hydrolase family 47
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PCV1 M9PCV1
Q8MS36 Q8MS36
Q9VK27 Q9VK27

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