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Alg7 Alg7 dolichyl-phosphate N-acetylglucosaminephosphotransferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34711, updated on 19-Jun-2024

Summary

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Official Symbol
Alg7provided by FlyBase
Official Full Name
Alg7 dolichyl-phosphate N-acetylglucosaminephosphotransferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0032477
Locus tag
Dmel_CG5287
See related
AllianceGenome:FB:FBgn0032477
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5287; dAlg7; Dmel\CG5287; DPAGT1
Summary
Predicted to enable UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity. Predicted to be part of UDP-N-acetylglucosamine transferase complex. Predicted to be integral component of membrane. Is expressed in adult head and embryonic proventriculus. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ij and congenital myasthenic syndrome 13. Orthologous to human DPAGT1 (dolichyl-phosphate N-acetylglucosaminephosphotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Alg7 in Genome Data Viewer
Location:
34A8-34A8; 2-47 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13179247..13183495)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13179247..13183495)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Scm-related gene containing four mbt domains Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Neighboring gene uncharacterized protein Neighboring gene Radial spoke head protein 1 Neighboring gene ER degradation enhancer, mannosidase alpha-like 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway. Arsham AM, et al. PLoS One, 2009 Jun 29. PMID 19562034, Free PMC Article
  2. Isolation of gene sets affected specifically by polyglutamine expression: implication of the TOR signaling pathway in neurodegeneration. Nelson B, et al. Cell Death Differ, 2005 Aug. PMID 15861189
  3. A genome-wide CRISPR screen identifies DPM1 as a modifier of DPAGT1 deficiency and ER stress. Dalton HM, et al. PLoS Genet, 2022 Sep. PMID 36166480, Free PMC Article
  4. The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. Bellen HJ, et al. Genetics, 2004 Jun. PMID 15238527, Free PMC Article
  5. Phenotype-based clustering of glycosylation-related genes by RNAi-mediated gene silencing. Yamamoto-Hino M, et al. Genes Cells, 2015 Jun. PMID 25940448, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in dolichol-linked oligosaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein N-linked glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of UDP-N-acetylglucosamine transferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Alg7 dolichyl-phosphate N-acetylglucosaminephosphotransferase
Names
Alg7-PA
CG5287-PA
NP_609608.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    13179247..13183495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135764.4 → NP_609608.1  Alg7 dolichyl-phosphate N-acetylglucosaminephosphotransferase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609608.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961K7, Q9VK30
    Related
    FBpp0080017
    Conserved Domains (1) summary
    cd06855
    Location:24 → 320
    GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VK30 Q9VK30

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