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ADGRD2 adhesion G protein-coupled receptor D2 [ Homo sapiens (human) ]

Gene ID: 347088, updated on 11-Apr-2024

Summary

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Official Symbol
ADGRD2provided by HGNC
Official Full Name
adhesion G protein-coupled receptor D2provided by HGNC
Primary source
HGNC:HGNC:18651
See related
Ensembl:ENSG00000180264 AllianceGenome:HGNC:18651
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR24; GPR144
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all
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Genomic context

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Location:
9q33.3
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (124450451..124478580)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (136648682..136676809)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (127212730..127240859)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100129034 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_106555 Neighboring gene uncharacterized LOC124902267 Neighboring gene proteasome 20S subunit beta 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127162229-127162772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127162773-127163315 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:127173920-127175119 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28985 Neighboring gene uncharacterized LOC105376270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127202115-127202615 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127212355-127212879 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127212880-127213404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127213405-127213929 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127244219-127244996 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:127248727-127248904 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20263 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127263337-127263838 Neighboring gene NR5A1 5' promoter region Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127274335-127274887 Neighboring gene nuclear receptor subfamily 5 group A member 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127297992-127298492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28986 Neighboring gene nuclear receptor subfamily 6 group A member 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:127336756-127337955 Neighboring gene RAN binding protein 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The Secretin GPCRs descended from the family of Adhesion GPCRs. Nordström KJ, et al. Mol Biol Evol, 2009 Jan. PMID 18845549
  2. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Bjarnadóttir TK, et al. Genomics, 2004 Jul. PMID 15203201
  3. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Hamann J, et al. Pharmacol Rev, 2015. PMID 25713288, Free PMC Article
  4. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article
  5. DNA sequence and analysis of human chromosome 9. Humphray SJ, et al. Nature, 2004 May 27. PMID 15164053, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adhesion G-protein coupled receptor D2
Names
G protein-coupled receptor PGR24
G-protein coupled receptor 144
G-protein coupled receptor GPR144

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395425.1 → NP_001382354.1  adhesion G-protein coupled receptor D2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL137846
    Consensus CDS
    CCDS94480.1
    UniProtKB/TrEMBL
    A0A8Q3SIF2, A0A9L9PY34
    Related
    ENSP00000512565.1, ENST00000696331.1
    Conserved Domains (4) summary
    cd00037
    Location:50 → 73
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd15255
    Location:692 → 954
    7tmB2_GPR144; orphan adhesion receptor GPR114, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    cl02559
    Location:646 → 685
    GPS; GPCR proteolysis site, GPS, motif
    cl22861
    Location:111 → 297
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    124450451..124478580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423337.1 → XP_047279293.1  adhesion G-protein coupled receptor D2 isoform X1

  2. XM_047423338.1 → XP_047279294.1  adhesion G-protein coupled receptor D2 isoform X1

  3. XM_047423339.1 → XP_047279295.1  adhesion G-protein coupled receptor D2 isoform X2

    UniProtKB/TrEMBL
    A0A8Q3SIF2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    136648682..136676809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362908.1 → XP_054218883.1  adhesion G-protein coupled receptor D2 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001161808.1: Suppressed sequence

    Description
    NM_001161808.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NM_182611.2: Suppressed sequence

    Description
    NM_182611.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z7M1.1 GenPept UniProtKB/Swiss-Prot:Q7Z7M1

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials
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