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kmg kumgang [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34706, updated on 2-Nov-2024

Summary

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Official Symbol
kmgprovided by FlyBase
Official Full Name
kumgangprovided by FlyBase
Primary source
FLYBASE:FBgn0032473
Locus tag
Dmel_CG5204
See related
AllianceGenome:FB:FBgn0032473
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.212; CG5204; Dmel\CG5204
Summary
Enables chromatin binding activity. Involved in regulation of gene expression and spermatogenesis. Located in nucleus. Is expressed in spermatocyte and testis. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 10. Orthologous to human ZFP64 (ZFP64 zinc finger protein) and ZNF335 (zinc finger protein 335). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See kmg in Genome Data Viewer
Location:
34A7-34A7; 2-47 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13160527..13163153)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13160527..13163153)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44199 Neighboring gene Protein kinase at 34A Neighboring gene DnaJ homolog Neighboring gene Sirtuin 1 Neighboring gene Scm-related gene containing four mbt domains Neighboring gene antisense RNA:CR46256

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Blocking promiscuous activation at cryptic promoters directs cell type-specific gene expression. Kim J, et al. Science, 2017 May 19. PMID 28522526, Free PMC Article
  2. Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination. Rosenberg MI, et al. Cell, 2002 May 17. PMID 12086602
  3. A transposon expression burst accompanies the activation of Y-chromosome fertility genes during Drosophila spermatogenesis. Lawlor MA, et al. Nat Commun, 2021 Nov 25. PMID 34824217, Free PMC Article
  4. Developmentally regulated alternate 3' end cleavage of nascent transcripts controls dynamic changes in protein expression in an adult stem cell lineage. Berry CW, et al. Genes Dev, 2022 Aug 1. PMID 36175033, Free PMC Article
  5. Polymorphism and Divergence of Novel Gene Expression Patterns in Drosophila melanogaster. Cridland JM, et al. Genetics, 2020 Sep. PMID 32737121, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kumgang
Names
CG5204-PA
kmg-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    13160527..13163153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135760.1 → NP_609604.1  kumgang [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609604.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VK36
    Related
    FBpp0080014, FBtr0080433
    Conserved Domains (1) summary
    sd00019
    Location:540 → 560
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VK36 Q9VK36

Gene LinkOut

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