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Plzf Promyelocytic leukemia zinc finger [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34622, updated on 2-Nov-2024

Summary

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Official Symbol
Plzfprovided by FlyBase
Official Full Name
Promyelocytic leukemia zinc fingerprovided by FlyBase
Primary source
FLYBASE:FBgn0032401
Locus tag
Dmel_CG6792
See related
AllianceGenome:FB:FBgn0032401
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg6792; CG6792; Dmel\CG6792; dPLZF; PLZF
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in Ras protein signal transduction and imaginal disc-derived wing vein specification. Predicted to be active in nucleus. Is expressed in organism. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Plzf in Genome Data Viewer
Location:
33B11-33B11; 2-45 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12046711..12048918, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12046711..12048918, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44589 Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol-specific phospholipase C X domain containing Neighboring gene Juvenile hormone Inducible-21 Neighboring gene Ribosomal protein L7-like Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Broad-complex, tramtrack, and bric-à-brac (BTB) proteins: Critical regulators of development. Chaharbakhshi E, et al. Genesis, 2016 Oct. PMID 27521773
  2. The Amino Acid Transporter JhI-21 Coevolves with Glutamate Receptors, Impacts NMJ Physiology, and Influences Locomotor Activity in Drosophila Larvae. Ziegler AB, et al. Sci Rep, 2016 Jan 25. PMID 26805723, Free PMC Article
  3. New candidate genes for heat resistance in Drosophila melanogaster are regulated by HSF. Jensen LT, et al. Cell Stress Chaperones, 2008 Summer. PMID 18759003, Free PMC Article
  4. The BTB/POZ-ZF transcription factor dPLZF is involved in Ras/ERK signaling during Drosophila wing development. Maeng O, et al. Mol Cells, 2012 May. PMID 22544070, Free PMC Article
  5. Drosophila BTB/POZ domains of "ttk group" can form multimers and selectively interact with each other. Bonchuk A, et al. J Mol Biol, 2011 Sep 23. PMID 21821048

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Ras protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in imaginal disc-derived wing vein specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
promyelocytic leukemia zinc finger
Names
CG6792-PA
CG6792-PB
Plzf-PA
Plzf-PB
promyelocytic leukemia zinc finger ortholog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    12046711..12048918 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298933.1 → NP_001285862.1  promyelocytic leukemia zinc finger, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285862.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TH6, Q9VKC4
    Conserved Domains (2) summary
    COG5048
    Location:193 → 403
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:244 → 264
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_135696.3 → NP_609540.2  promyelocytic leukemia zinc finger, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609540.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TH6, Q9VKC4
    Related
    FBpp0079889
    Conserved Domains (2) summary
    COG5048
    Location:193 → 403
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:244 → 264
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95TH6 Q95TH6
Q9VKC4 Q9VKC4

Gene LinkOut

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