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kek2 kekkon 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34582, updated on 2-Nov-2024

Summary

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Official Symbol
kek2provided by FlyBase
Official Full Name
kekkon 2provided by FlyBase
Primary source
FLYBASE:FBgn0015400
Locus tag
Dmel_CG4977
See related
AllianceGenome:FB:FBgn0015400
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4977; CT15962; Dmel\CG4977; kek-2; Kek2; NB7
Summary
Predicted to be located in plasma membrane. Is expressed in several structures, including head; larval peripheral nervous system; larval ventral nerve cord; presumptive embryonic/larval peripheral nervous system; and ventral midline of embryo. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See kek2 in Genome Data Viewer
Location:
32F3-32F4; 2-44 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11581937..11626883)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11581937..11626883)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44494 Neighboring gene long non-coding RNA:CR44495 Neighboring gene long non-coding RNA:CR44496 Neighboring gene Mst33A Neighboring gene Accessory gland-specific peptide 33A Neighboring gene sperm-associated antigen 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila kekkon genes: novel members of both the leucine-rich repeat and immunoglobulin superfamilies expressed in the CNS. Musacchio M, et al. Dev Biol, 1996 Aug 25. PMID 8812109
  2. Chronic exposure to titanium dioxide nanoparticles induces deficits of locomotor behavior by disrupting the development of NMJ in Drosophila. Zhang X, et al. Sci Total Environ, 2023 Aug 25. PMID 37196938
  3. Conservation of an inhibitor of the epidermal growth factor receptor, Kekkon1, in dipterans. Derheimer FA, et al. Genetics, 2004 Jan. PMID 15020419, Free PMC Article
  4. Comparative analysis of the Kekkon molecules, related members of the LIG superfamily. MacLaren CM, et al. Dev Genes Evol, 2004 Jul. PMID 15179511
  5. Bipartite inhibition of Drosophila epidermal growth factor receptor by the extracellular and transmembrane domains of Kekkon1. Alvarado D, et al. Genetics, 2004 May. PMID 15166146, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
kekkon 2
Names
CG4977-PA
Kekkon-2
kek2-PA
kekkon

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    11581937..11626883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078827.3 → NP_523551.1  kekkon 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523551.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D1Z375, P91644, Q9VKG1
    Related
    FBpp0079836
    Conserved Domains (6) summary
    cd00116
    Location:80 → 187
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam07679
    Location:258 → 361
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:34 → 52
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:79 → 138
    LRR_8; Leucine rich repeat
    pfam13895
    Location:263 → 361
    Ig_2; Immunoglobulin domain
    cl15307
    Location:207 → 256
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P91644 P91644
Q2XY26 Q2XY26
Q9VKG1 Q9VKG1

Gene LinkOut

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