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ZNF879 zinc finger protein 879 [ Homo sapiens (human) ]

Gene ID: 345462, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF879provided by HGNC
Official Full Name
zinc finger protein 879provided by HGNC
Primary source
HGNC:HGNC:37273
See related
Ensembl:ENSG00000234284 AllianceGenome:HGNC:37273
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DKFZp686E2433
Summary
This gene encodes a kruppel-associated box-containing zinc finger protein (KRAB-ZFP). The encoded protein contains an N-terminal kruppel-associated box (KRAB) domain and thirteen C-terminal C2H2-type zinc finger domains. The KRAB-ZFPs represent the largest family of mammalian transcriptional repressors, which function through the recruitment of the nuclear co-factor KRAB-Associated Protein 1 (KAP1), to engage histone modifiers and induce heterochromatin formation. [provided by RefSeq, Jul 2017]
Expression
Broad expression in testis (RPKM 2.9), thyroid (RPKM 1.6) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
5q35.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (179023804..179035064)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (179576953..179588262)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (178450805..178462065)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 454 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83773 Neighboring gene F-box and WD repeat domain containing 2 pseudogene Neighboring gene glutamate metabotropic receptor 6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:178450433-178450934 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:178487693-178488228 Neighboring gene zinc finger protein 354C Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:178594089-178594590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:178608229-178608956 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:178611336-178611936 Neighboring gene uncharacterized LOC124900195 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:178619033-178619724

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Kruppel-associated box (KRAB) proteins in the adaptive immune system. Santoni de Sio FR. Nucleus, 2014 Mar-Apr. PMID 24699165, Free PMC Article
  2. KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks. Imbeault M, et al. Nature, 2017 Mar 23. PMID 28273063
  3. Zinc fingers function cooperatively with KRAB domain for nuclear localization of KRAB-containing zinc finger proteins. Wang W, et al. PLoS One, 2014. PMID 24647005, Free PMC Article
  4. Evolution of KRAB-containing zinc finger proteins and their roles in species evolution. Wang J, et al. Yi Chuan, 2016 Nov 20. PMID 27867147
  5. Cys2His2 zinc finger protein family: classification, functions, and major members. Razin SV, et al. Biochemistry (Mosc), 2012 Mar. PMID 22803940

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 879

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136116.3 → NP_001129588.1  zinc finger protein 879

    See identical proteins and their annotated locations for NP_001129588.1

    Status: REVIEWED

    Source sequence(s)
    AC104117, AK300504, BM971752, BX114675, BX648737, DC350553
    Consensus CDS
    CCDS47352.1
    UniProtKB/Swiss-Prot
    B4DU55
    Related
    ENSP00000414887.2, ENST00000444149.7
    Conserved Domains (3) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:202 → 558
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486 → 506
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001353372.2 → NP_001340301.1  zinc finger protein 879

    Status: REVIEWED

    Source sequence(s)
    AC104117, BM971752
    Consensus CDS
    CCDS47352.1
    UniProtKB/Swiss-Prot
    B4DU55
    Conserved Domains (3) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:202 → 558
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486 → 506
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001353373.2 → NP_001340302.1  zinc finger protein 879

    Status: REVIEWED

    Source sequence(s)
    AC104117, BM971752
    Consensus CDS
    CCDS47352.1
    UniProtKB/Swiss-Prot
    B4DU55
    Conserved Domains (3) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:202 → 558
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486 → 506
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001353374.2 → NP_001340303.1  zinc finger protein 879

    Status: REVIEWED

    Source sequence(s)
    AC104117, BM971752
    Consensus CDS
    CCDS47352.1
    UniProtKB/Swiss-Prot
    B4DU55
    Conserved Domains (3) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:202 → 558
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486 → 506
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    179023804..179035064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534551.3 → XP_011532853.1  zinc finger protein 879 isoform X1

    See identical proteins and their annotated locations for XP_011532853.1

    UniProtKB/Swiss-Prot
    B4DU55
    Conserved Domains (3) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:202 → 558
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486 → 506
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_047417144.1 → XP_047273100.1  zinc finger protein 879 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    179576953..179588262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352508.1 → XP_054208483.1  zinc finger protein 879 isoform X1

    UniProtKB/Swiss-Prot
    B4DU55

  2. XM_054352509.1 → XP_054208484.1  zinc finger protein 879 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B4DU55.2 GenPept UniProtKB/Swiss-Prot:B4DU55

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