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Ubc2 Ubiquitin conjugating enzyme 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34487, updated on 2-Nov-2024

Summary

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Official Symbol
Ubc2provided by FlyBase
Official Full Name
Ubiquitin conjugating enzyme 2provided by FlyBase
Primary source
FLYBASE:FBgn0015320
Locus tag
Dmel_CG6720
See related
AllianceGenome:FB:FBgn0015320
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6720; Dmel\CG6720; l(2)k13206; ubcD2; UbcD2; UBCD2
Summary
Enables ubiquitin-protein transferase activity. Involved in lipid storage. Predicted to be active in nucleus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; central brain primordium; ganglia; and mesoderm. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human UBE2E1 (ubiquitin conjugating enzyme E2 E1); UBE2E2 (ubiquitin conjugating enzyme E2 E2); and UBE2E3 (ubiquitin conjugating enzyme E2 E3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Ubc2 in Genome Data Viewer
Location:
32A5-32A5; 2-43 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10765010..10768006, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10765010..10768006, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mir-9378 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Essential roles of Windei and nuclear monoubiquitination of Eggless/SETDB1 in transposon silencing. Osumi K, et al. EMBO Rep, 2019 Dec 5. PMID 31576653, Free PMC Article
  2. Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1. Daou S, et al. Nat Commun, 2018 Oct 22. PMID 30349006, Free PMC Article
  3. Identification of a novel family of ubiquitin-conjugating enzymes with distinct amino-terminal extensions. Matuschewski K, et al. J Biol Chem, 1996 Feb 2. PMID 8576256
  4. UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination. Hans F, et al. J Biol Chem, 2014 Jul 4. PMID 24825905, Free PMC Article
  5. Encore facilitates SCF-Ubiquitin-proteasome-dependent proteolysis during Drosophila oogenesis. Ohlmeyer JT, et al. Development, 2003 Dec. PMID 14623823

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid storage IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin conjugating enzyme 2
Names
CG6720-PA
CG6720-PB
CG6720-PC
CG6720-PD
Ubc2-PA
Ubc2-PB
Ubc2-PC
Ubc2-PD
NP_001260362.1
NP_001285814.1
NP_477137.1
NP_723616.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10765010..10768006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273433.1 → NP_001260362.1  ubiquitin conjugating enzyme 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260362.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P52485, Q9VKQ4
    UniProtKB/TrEMBL
    Q541C3
    Conserved Domains (2) summary
    COG5078
    Location:86 → 231
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00179
    Location:90 → 227
    UQ_con; Ubiquitin-conjugating enzyme

  2. NM_001298885.1 → NP_001285814.1  ubiquitin conjugating enzyme 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285814.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P52485, Q9VKQ4
    UniProtKB/TrEMBL
    Q541C3
    Conserved Domains (2) summary
    COG5078
    Location:86 → 231
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00179
    Location:90 → 227
    UQ_con; Ubiquitin-conjugating enzyme

  3. NM_057789.4 → NP_477137.1  ubiquitin conjugating enzyme 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477137.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P52485, Q9VKQ4
    UniProtKB/TrEMBL
    Q541C3
    Related
    FBpp0079704
    Conserved Domains (2) summary
    COG5078
    Location:86 → 231
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00179
    Location:90 → 227
    UQ_con; Ubiquitin-conjugating enzyme

  4. NM_164943.2 → NP_723616.1  ubiquitin conjugating enzyme 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723616.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P52485, Q9VKQ4
    UniProtKB/TrEMBL
    Q541C3
    Related
    FBpp0079705
    Conserved Domains (2) summary
    COG5078
    Location:86 → 231
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00179
    Location:90 → 227
    UQ_con; Ubiquitin-conjugating enzyme
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52485.1 P52485
Q541C3 Q541C3

Gene LinkOut

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