U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

gny garnysstan [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34409, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
gnyprovided by FlyBase
Official Full Name
garnysstanprovided by FlyBase
Primary source
FLYBASE:FBgn0032234
Locus tag
Dmel_CG5091
See related
AllianceGenome:FB:FBgn0032234
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
alg6; CG5091; dAlg6; Dalg6; Dmel\CG5091; Gny[
Summary
Predicted to enable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity. Involved in chitin-based cuticle development. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ic. Orthologous to human ALG6 (ALG6 alpha-1,3-glucosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See gny in Genome Data Viewer
Location:
31D11-31D11; 2-41 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10380103..10382864)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10380103..10382864)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene rhomboid-5 Neighboring gene uncharacterized protein Neighboring gene defective proboscis extension response 19 Neighboring gene uncharacterized protein Neighboring gene Cyclin-dependent kinase 1 Neighboring gene mitochondrial ribosomal protein S7

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Alg5 ortholog Wollknäuel is essential for correct epidermal differentiation during Drosophila late embryogenesis. Shaik KS, et al. Glycobiology, 2011 Jun. PMID 21199819
  2. The glucosyltransferase Xiantuan of the endoplasmic reticulum specifically affects E-Cadherin expression and is required for gastrulation movements in Drosophila. Zhang Y, et al. Dev Biol, 2014 Jun 15. PMID 24681004
  3. Diversity and functions of protein glycosylation in insects. Walski T, et al. Insect Biochem Mol Biol, 2017 Apr. PMID 28232040
  4. Phenotype-based clustering of glycosylation-related genes by RNAi-mediated gene silencing. Yamamoto-Hino M, et al. Genes Cells, 2015 Jun. PMID 25940448, Free PMC Article
  5. Molecular and comparative genetics of mental retardation. Inlow JK, et al. Genetics, 2004 Feb. PMID 15020472, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chitin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dolichol-linked oligosaccharide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
garnysstan
Names
CG5091-PA
CG5091-PB
gny-PA
gny-PB
NP_001260338.1
NP_609393.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10380103..10382864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135549.4 → NP_609393.1  garnysstan, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609393.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q960Z1, Q9VKX7
    UniProtKB/TrEMBL
    M9PB91
    Related
    FBpp0079595
    Conserved Domains (1) summary
    pfam03155
    Location:30 → 463
    Alg6_Alg8; ALG6, ALG8 glycosyltransferase family

  2. NM_001273409.1 → NP_001260338.1  garnysstan, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260338.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q960Z1, Q9VKX7
    UniProtKB/TrEMBL
    M9PB91
    Conserved Domains (1) summary
    pfam03155
    Location:30 → 463
    Alg6_Alg8; ALG6, ALG8 glycosyltransferase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PB91 M9PB91
Q9VKX7.2 Q9VKX7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous