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REPTOR-BP REPTOR-binding partner [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34371, updated on 2-Nov-2024

Summary

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Official Symbol
REPTOR-BPprovided by FlyBase
Official Full Name
REPTOR-binding partnerprovided by FlyBase
Primary source
FLYBASE:FBgn0032202
Locus tag
Dmel_CG18619
See related
AllianceGenome:FB:FBgn0032202
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RH73910; CG18619; DM20; Dmel\CG18619; Reptor-BP
Summary
Enables chromatin binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in TORC1 signaling; positive regulation of DNA-templated transcription; and response to starvation. Located in nucleus. Is expressed in several structures, including central brain primordium; ganglia; larval nervous system; and ventral nerve cord primordium. Orthologous to human CREBL2 (cAMP responsive element binding protein like 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See REPTOR-BP in Genome Data Viewer
Location:
31B1-31B1; 2-40 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10264125..10265229)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10264125..10265229)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Phosphatase and tensin homolog Neighboring gene Repressor splicing factor 1 Neighboring gene MOB kinase activator 3 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein visualization and manipulation in Drosophila through the use of epitope tags recognized by nanobodies. Xu J, et al. Elife, 2022 Jan 25. PMID 35076390, Free PMC Article
  2. The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation. Bjedov I, et al. Genes (Basel), 2020 Sep 3. PMID 32899412, Free PMC Article
  3. Dietary Adaptation of Microbiota in Drosophila Requires NF-κB-Dependent Control of the Translational Regulator 4E-BP. Vandehoef C, et al. Cell Rep, 2020 Jun 9. PMID 32521261, Free PMC Article
  4. REPTOR and REPTOR-BP Regulate Organismal Metabolism and Transcription Downstream of TORC1. Tiebe M, et al. Dev Cell, 2015 May 4. PMID 25920570, Free PMC Article
  5. B-ZIP proteins encoded by the Drosophila genome: evaluation of potential dimerization partners. Fassler J, et al. Genome Res, 2002 Aug. PMID 12176927, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
REPTOR-binding partner
Names
CG18619-PA
CG18619-PB
CG18619-PC
CG18619-PD
REPTOR-BP-PA
REPTOR-BP-PB
REPTOR-BP-PC
REPTOR-BP-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10264125..10265229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164904.2 → NP_723547.1  REPTOR-binding partner, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723547.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPC7
    Related
    FBpp0088676
    Conserved Domains (2) summary
    cd14686
    Location:43 → 88
    bZIP; coiled coil [structural motif]
    cl21462
    Location:42 → 88
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  2. NM_164903.2 → NP_723546.1  REPTOR-binding partner, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723546.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MYS1
    Related
    FBpp0088678
    Conserved Domains (1) summary
    cd14709
    Location:41 → 96
    bZIP_CREBL2; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein-like 2 (CREBL2): a DNA-binding and dimerization domain

  3. NM_164905.3 → NP_723548.1  REPTOR-binding partner, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723548.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPC6
    Related
    FBpp0088677
    Conserved Domains (2) summary
    cd14686
    Location:42 → 87
    bZIP; coiled coil [structural motif]
    cl21462
    Location:41 → 87
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  4. NM_135519.3 → NP_609363.1  REPTOR-binding partner, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609363.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IPC6, Q8IPC7, Q8MYS1, Q9VL14
    Related
    FBpp0088679
    Conserved Domains (1) summary
    cd14709
    Location:42 → 97
    bZIP_CREBL2; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein-like 2 (CREBL2): a DNA-binding and dimerization domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VL14.2 Q9VL14

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