Bcs1 Bcs1 chaperone [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Bcs1provided by FlyBase
Official Full Name: Bcs1 chaperoneprovided by FlyBase
Primary source: FLYBASE:FBgn0032195
Locus tag: Dmel_CG4908
See related: AllianceGenome:FB:FBgn0032195
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4908; Dmel\CG4908
Summary: Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be involved in mitochondrial respiratory chain complex III assembly and protein insertion into mitochondrial inner membrane from matrix. Predicted to be active in mitochondrial inner membrane. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval muscle system; and endoderm. Human ortholog(s) of this gene implicated in Bjornstad syndrome; GRACILE syndrome; and mitochondrial complex III deficiency nuclear type 1. Orthologous to human BCS1L (BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10222657..10224447)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10222657..10224447)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISM Inferred from Sequence Model more info	PubMed
enables mitochondrial protein-transporting ATPase activity	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrial respiratory chain complex III assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial respiratory chain complex III assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein insertion into mitochondrial inner membrane from matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein insertion into mitochondrial inner membrane from matrix	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein insertion into mitochondrial inner membrane from matrix	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

NP_609358.1

NP_723532.1

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The following sections contain reference sequences that belong to a specific genome build. Explain