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Snx17 Sorting nexin 17 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34354, updated on 18-Sep-2024

Summary

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Official Symbol
Snx17provided by FlyBase
Official Full Name
Sorting nexin 17provided by FlyBase
Primary source
FLYBASE:FBgn0032191
Locus tag
Dmel_CG5734
See related
AllianceGenome:FB:FBgn0032191
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5734; Dmel\CG5734; DmSNX17; snx17
Summary
Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in intracellular protein transport. Predicted to be active in early endosome. Orthologous to several human genes including SNX17 (sorting nexin 17). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Snx17 in Genome Data Viewer
Location:
31B1-31B1; 2-40 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10204757..10206961, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10204757..10206961, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44845 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role of Drosophila HP1 in euchromatic gene expression. Cryderman DE, et al. Dev Dyn, 2005 Mar. PMID 15704177
  2. Snazarus and its human ortholog SNX25 modulate autophagic flux. Lauzier A, et al. J Cell Sci, 2022 Mar 1. PMID 34821359
  3. SNX3 controls Wingless/Wnt secretion through regulating retromer-dependent recycling of Wntless. Zhang P, et al. Cell Res, 2011 Dec. PMID 22041890, Free PMC Article
  4. Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling. McNally KE, et al. Nat Cell Biol, 2017 Oct. PMID 28892079, Free PMC Article
  5. An SH3PX1-Dependent Endocytosis-Autophagy Network Restrains Intestinal Stem Cell Proliferation by Counteracting EGFR-ERK Signaling. Zhang P, et al. Dev Cell, 2019 May 20. PMID 31006650, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sorting nexin 17
Names
CG5734-PA
Snx17-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10204757..10206961 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135509.3 → NP_609353.1  sorting nexin 17 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609353.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VL28
    Related
    FBpp0079550, FBtr0079960
    Conserved Domains (2) summary
    cd06885
    Location:7 → 108
    PX_SNX17_31; The phosphoinositide binding Phox Homology domain of Sorting Nexins 17 and 31
    cd13337
    Location:280 → 391
    FERM-like_C_SNX17; Atypical FERM-like domain C-lobe of Sorting nexin 17
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VL28 Q9VL28

Gene LinkOut

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