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DYNLT4 dynein light chain Tctex-type 4 [ Homo sapiens (human) ]

Gene ID: 343521, updated on 5-Mar-2024

Summary

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Official Symbol
DYNLT4provided by HGNC
Official Full Name
dynein light chain Tctex-type 4provided by HGNC
Primary source
HGNC:HGNC:32315
See related
Ensembl:ENSG00000188396 MIM:611713; AllianceGenome:HGNC:32315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCTEX1D4
Summary
Enables protein phosphatase 1 binding activity. Predicted to be involved in microtubule-based movement. Located in acrosomal vesicle; cytoskeleton; and sperm flagellum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in esophagus (RPKM 3.3), appendix (RPKM 2.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
1p34.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (44805893..44807351, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (44677047..44678505, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (45271565..45273023, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:45245573-45246073 Neighboring gene ribosomal protein S15a pseudogene 11 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 818 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:45251699-45252384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:45252385-45253070 Neighboring gene bestrophin 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:45257343-45258034 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:45258727-45259416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:45265053-45265721 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 820 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 949 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:45271492-45272342 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:45272786-45273985 Neighboring gene polo like kinase 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:45274044-45274893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 953 Neighboring gene BTB domain containing 19 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 821 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr1:45284771-45285427 and GRCh37_chr1:45285428-45286084 Neighboring gene RNA, U5E small nuclear 6, pseudogene Neighboring gene patched 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TCTEX1D4 interactome in human testis: unraveling the function of dynein light chain in spermatozoa. Freitas MJ, et al. OMICS, 2014 Apr. PMID 24606217, Free PMC Article
  2. Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors. Meng Q, et al. J Biol Chem, 2006 Dec 1. PMID 16982625
  3. TCTEX1D4, a novel protein phosphatase 1 interactor: connecting the phosphatase to the microtubule network. Korrodi-Gregório L, et al. Biol Open, 2013 May 15. PMID 23789093, Free PMC Article
  4. Identification of the human testis protein phosphatase 1 interactome. Fardilha M, et al. Biochem Pharmacol, 2011 Nov 15. PMID 21382349
  5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. 40 novel TCTEX1D4 interactors in human spermatozoa have been identified.
    Title: TCTEX1D4 interactome in human testis: unraveling the function of dynein light chain in spermatozoa.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase 1 binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axoneme IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in microtubule organizing center IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dynein light chain Tctex-type 4
Names
Tctex1 domain containing 4
Tctex2 beta
novel Tctex-1 family domain-containing protein
protein N22.1
tctex-2-beta
tctex1 domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013632.4 → NP_001013654.1  dynein light chain Tctex-type 4

    See identical proteins and their annotated locations for NP_001013654.1

    Status: VALIDATED

    Source sequence(s)
    AL592166, BC092499, DQ132441
    Consensus CDS
    CCDS30699.1
    UniProtKB/Swiss-Prot
    Q5JR98
    Conserved Domains (1) summary
    cl41776
    Location:108 → 221
    DLC-like_SF; dynein light chain (DLC)-like domain superfamily

  2. NM_001377534.1 → NP_001364463.1  dynein light chain Tctex-type 4

    Status: VALIDATED

    Source sequence(s)
    AL592166
    Consensus CDS
    CCDS30699.1
    UniProtKB/Swiss-Prot
    Q5JR98
    Related
    ENSP00000341803.2, ENST00000339355.3
    Conserved Domains (1) summary
    cl41776
    Location:108 → 221
    DLC-like_SF; dynein light chain (DLC)-like domain superfamily

  3. NM_001377535.1 → NP_001364464.1  dynein light chain Tctex-type 4

    Status: VALIDATED

    Source sequence(s)
    AL592166
    Consensus CDS
    CCDS30699.1
    UniProtKB/Swiss-Prot
    Q5JR98
    Conserved Domains (1) summary
    cl41776
    Location:108 → 221
    DLC-like_SF; dynein light chain (DLC)-like domain superfamily

  4. NM_001377536.1 → NP_001364465.1  dynein light chain Tctex-type 4

    Status: VALIDATED

    Source sequence(s)
    AL592166
    Consensus CDS
    CCDS30699.1
    UniProtKB/Swiss-Prot
    Q5JR98
    Conserved Domains (1) summary
    cl41776
    Location:108 → 221
    DLC-like_SF; dynein light chain (DLC)-like domain superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    44805893..44807351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419617.1 → XP_047275573.1  dynein light chain Tctex-type 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5JR98

  2. XM_047419619.1 → XP_047275575.1  dynein light chain Tctex-type 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5JR98

  3. XM_047419618.1 → XP_047275574.1  dynein light chain Tctex-type 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5JR98
    Related
    ENSP00000501642.1, ENST00000675259.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    44677047..44678505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336368.1 → XP_054192343.1  dynein light chain Tctex-type 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5JR98

  2. XM_054336369.1 → XP_054192344.1  dynein light chain Tctex-type 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5JR98

  3. XM_054336370.1 → XP_054192345.1  dynein light chain Tctex-type 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5JR98
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5JR98.1 GenPept UniProtKB/Swiss-Prot:Q5JR98

Gene LinkOut

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