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OR10R2 olfactory receptor family 10 subfamily R member 2 [ Homo sapiens (human) ]

Gene ID: 343406, updated on 11-Apr-2024

Summary

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Official Symbol
OR10R2provided by HGNC
Official Full Name
olfactory receptor family 10 subfamily R member 2provided by HGNC
Primary source
HGNC:HGNC:14820
See related
Ensembl:ENSG00000198965 AllianceGenome:HGNC:14820
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR1-8; OR10R2Q
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

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Location:
1q23.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (158472220..158480936)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (157609298..157618014)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (158442010..158450726)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene EI24 pseudogene 2 Neighboring gene uncharacterized LOC107985212 Neighboring gene olfactory receptor family 10 subfamily K member 1 Neighboring gene uncharacterized LOC107985213 Neighboring gene olfactory receptor family 10 subfamily R member 3 pseudogene Neighboring gene olfactory receptor family 10 subfamily R member 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DEFOG: a practical scheme for deciphering families of genes. Fuchs T, et al. Genomics, 2002 Sep. PMID 12213199
  2. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
  3. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables odorant binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
olfactory receptor 10R2
Names
olfactory receptor OR1-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004472.1 → NP_001004472.1  olfactory receptor 10R2 isoform 1

    See identical proteins and their annotated locations for NP_001004472.1

    Status: VALIDATED

    Source sequence(s)
    AB065640
    UniProtKB/Swiss-Prot
    Q5VWM8, Q6IFS1, Q8NGX6, Q96R61
    UniProtKB/TrEMBL
    A0A126GVU0
    Related
    ENSP00000493033.1, ENST00000641400.1
    Conserved Domains (2) summary
    pfam00001
    Location:61 → 305
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:51 → 328
    7tm_4; Olfactory receptor

  2. NM_001395749.1 → NP_001382678.1  olfactory receptor 10R2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL365440
    Consensus CDS
    CCDS91076.1
    UniProtKB/TrEMBL
    A0A126GVZ9, A0A286YEZ2
    Related
    ENSP00000493160.1, ENST00000641067.1
    Conserved Domains (1) summary
    cd15225
    Location:36 → 310
    7tmA_OR10A-like; olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    158472220..158480936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    157609298..157618014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NGX6.3 GenPept UniProtKB/Swiss-Prot:Q8NGX6

Gene LinkOut

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