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ZSCAN22 zinc finger and SCAN domain containing 22 [ Homo sapiens (human) ]

Gene ID: 342945, updated on 11-Apr-2024

Summary

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Official Symbol
ZSCAN22provided by HGNC
Official Full Name
zinc finger and SCAN domain containing 22provided by HGNC
Primary source
HGNC:HGNC:4929
See related
Ensembl:ENSG00000182318 MIM:165260; AllianceGenome:HGNC:4929
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HKR2; ZNF50
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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Location:
19q13.43
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58326994..58342332)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61423408..61438747)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58838360..58853698)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF8-ERVK3-1 readthrough (NMD candidate) Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:58816949-58817449 Neighboring gene Sharpr-MPRA regulatory region 7439 Neighboring gene endogenous retrovirus group K3 member 1 Neighboring gene uncharacterized LOC105372480 Neighboring gene zinc finger protein 470 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58838245-58838987 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:58849877-58850378 Neighboring gene microRNA 6806 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:58858160-58858660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:58858661-58859161 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15186 Neighboring gene alpha-1-B glycoprotein Neighboring gene A1BG antisense RNA 1 Neighboring gene zinc finger protein 446 pseudogene Neighboring gene zinc finger protein 497

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Assignment of the human GLI2 gene to 2q14 by fluorescence in situ hybridization. Matsumoto N, et al. Genomics, 1996 Aug 15. PMID 8812445
  2. 2058 expressed sequence tags (ESTs) from a human fetal lung cDNA library. Sudo K, et al. Genomics, 1994 Nov 15. PMID 7698749
  3. The GLI-Kruppel family of human genes. Ruppert JM, et al. Mol Cell Biol, 1988 Aug. PMID 2850480, Free PMC Article
  4. Characterization and mapping of human genes encoding zinc finger proteins. Bray P, et al. Proc Natl Acad Sci U S A, 1991 Nov 1. PMID 1946370, Free PMC Article
  5. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. Lichter P, et al. Genomics, 1992 Aug. PMID 1505991

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC126679, MGC138482

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger and SCAN domain-containing protein 22
Names
GLI-Kruppel family member HKR2
krueppel-related zinc finger protein 2
zinc finger protein 50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321116.2 → NP_001308045.1  zinc finger and SCAN domain-containing protein 22 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC010642, AC012313, AK128716
    Consensus CDS
    CCDS12975.1
    UniProtKB/Swiss-Prot
    P10073, Q15922, Q7Z3L8
    Conserved Domains (3) summary
    COG5048
    Location:174 → 482
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:326 → 346
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:45 → 129
    SCAN; SCAN domain

  2. NM_001321117.2 → NP_001308046.1  zinc finger and SCAN domain-containing protein 22 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC010642, AC012313, AK128716, BC143446, DA335630
    UniProtKB/Swiss-Prot
    P10073
    Conserved Domains (2) summary
    smart00431
    Location:45 → 153
    SCAN; leucine rich region
    pfam02023
    Location:45 → 130
    SCAN; SCAN domain

  3. NM_181846.3 → NP_862829.1  zinc finger and SCAN domain-containing protein 22 isoform 1

    See identical proteins and their annotated locations for NP_862829.1

    Status: VALIDATED

    Source sequence(s)
    AC010642, AC012313, BC112277
    Consensus CDS
    CCDS12975.1
    UniProtKB/Swiss-Prot
    P10073, Q15922, Q7Z3L8
    Related
    ENSP00000332433.3, ENST00000329665.5
    Conserved Domains (3) summary
    COG5048
    Location:174 → 482
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:326 → 346
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:45 → 129
    SCAN; SCAN domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    58326994..58342332
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526917.3 → XP_011525219.1  zinc finger and SCAN domain-containing protein 22 isoform X1

    See identical proteins and their annotated locations for XP_011525219.1

    UniProtKB/Swiss-Prot
    P10073, Q15922, Q7Z3L8
    Conserved Domains (3) summary
    COG5048
    Location:174 → 482
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:326 → 346
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:45 → 129
    SCAN; SCAN domain

  2. XM_006723192.4 → XP_006723255.1  zinc finger and SCAN domain-containing protein 22 isoform X1

    See identical proteins and their annotated locations for XP_006723255.1

    UniProtKB/Swiss-Prot
    P10073, Q15922, Q7Z3L8
    Conserved Domains (3) summary
    COG5048
    Location:174 → 482
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:326 → 346
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:45 → 129
    SCAN; SCAN domain

  3. XM_017026746.2 → XP_016882235.1  zinc finger and SCAN domain-containing protein 22 isoform X2

    Conserved Domains (2) summary
    smart00431
    Location:45 → 153
    SCAN; leucine rich region
    pfam02023
    Location:45 → 130
    SCAN; SCAN domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    61423408..61438747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320852.1 → XP_054176827.1  zinc finger and SCAN domain-containing protein 22 isoform X2

  2. XM_054320850.1 → XP_054176825.1  zinc finger and SCAN domain-containing protein 22 isoform X1

    UniProtKB/Swiss-Prot
    P10073, Q15922, Q7Z3L8

  3. XM_054320851.1 → XP_054176826.1  zinc finger and SCAN domain-containing protein 22 isoform X1

    UniProtKB/Swiss-Prot
    P10073, Q15922, Q7Z3L8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10073.2 GenPept UniProtKB/Swiss-Prot:P10073

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