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CG4364 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34287, updated on 2-Nov-2024

Summary

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Official Symbol
CG4364provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0032138
Locus tag
Dmel_CG4364
See related
AllianceGenome:FB:FBgn0032138
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG4364
Summary
Predicted to enable RNA binding activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of PeBoW complex. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; mesoderm; and posterior endoderm. Orthologous to human PES1 (pescadillo ribosomal biogenesis factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See CG4364 in Genome Data Viewer
Location:
30C5-30C6; 2-36 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9708921..9711271, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9708921..9711271, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene hoi-polloi Neighboring gene uncharacterized protein Neighboring gene pelota Neighboring gene Nckx30C Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Intertissue control of the nucleolus via a myokine-dependent longevity pathway. Demontis F, et al. Cell Rep, 2014 Jun 12. PMID 24882005, Free PMC Article
  2. Whole-genome analysis reveals a strong positional bias of conserved dMyc-dependent E-boxes. Hulf T, et al. Mol Cell Biol, 2005 May. PMID 15831447, Free PMC Article
  3. Misregulation of Nucleoporins 98 and 96 leads to defects in protein synthesis that promote hallmarks of tumorigenesis. Pulianmackal AJ, et al. Dis Model Mech, 2022 Mar 1. PMID 35107131, Free PMC Article
  4. Over-expression of a novel nuclear interactor of Suppressor of fused, the Drosophila myelodysplasia/myeloid leukaemia factor, induces abnormal morphogenesis associated with increased apoptosis and DNA synthesis. Fouix S, et al. Genes Cells, 2003 Nov. PMID 14622141
  5. Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila. Demontis F, et al. Development, 2009 Mar. PMID 19211682, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of PeBoW complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG4364-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    9708921..9711271 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135461.4 → NP_609305.1  uncharacterized protein Dmel_CG4364 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609305.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VL96
    Related
    FBpp0079445
    Conserved Domains (3) summary
    COG5163
    Location:1 → 601
    NOP7; Protein required for biogenesis of the 60S ribosomal subunit [Translation, ribosomal structure and biogenesis]
    pfam06732
    Location:7 → 268
    Pescadillo_N; Pescadillo N-terminus
    pfam16589
    Location:323 → 413
    BRCT_2; BRCT domain, a BRCA1 C-terminus domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VL96.1 Q9VL96

Gene LinkOut

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