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brwl brickwall [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34275, updated on 2-Nov-2024

Summary

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Official Symbol
brwlprovided by FlyBase
Official Full Name
brickwallprovided by FlyBase
Primary source
FLYBASE:FBgn0032130
Locus tag
Dmel_CG3838
See related
AllianceGenome:FB:FBgn0032130
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.445; bs09e08.y1; CC20; CG3838; Dmel\CG3838; NEST:bs09e08
Summary
Predicted to enable DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including anlage in statu nascendi; cuboidal/columnar epithelium; gut section; head epidermis primordium; and mesoderm. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See brwl in Genome Data Viewer
Location:
30B12-30B12; 2-35 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9568890..9573572)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9568890..9573572)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene junctophilin Neighboring gene long non-coding RNA:CR44149 Neighboring gene Mitochondrial trifunctional protein alpha subunit Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43621 Neighboring gene glial cells missing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolution of the Drosophila melanogaster Chromatin Landscape and Its Associated Proteins. Parey E, et al. Genome Biol Evol, 2019 Mar 1. PMID 30689829, Free PMC Article
  2. Stonewall and Brickwall: Two Partially Redundant Determinants Required for the Maintenance of Female Germline in Drosophila. Shukla V, et al. G3 (Bethesda), 2018 May 31. PMID 29669801, Free PMC Article
  3. Anterior repression of a Drosophila stripe enhancer requires three position-specific mechanisms. Andrioli LP, et al. Development, 2002 Nov. PMID 12397102
  4. The MADF-BESS domain factor Dip3 potentiates synergistic activation by Dorsal and Twist. Bhaskar V, et al. Gene, 2002 Oct 16. PMID 12459265
  5. Gene amplification as a developmental strategy: isolation of two developmental amplicons in Drosophila. Claycomb JM, et al. Dev Cell, 2004 Jan. PMID 14723854

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. brwl and stwl likely share a common MADF-BESS ancestor and they are expressed in overlapping spatiotemporal domains to ensure robust development of the female germline.
    Title: Stonewall and Brickwall: Two Partially Redundant Determinants Required for the Maintenance of Female Germline in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
brickwall
Names
CG3838-PA
CG3838-PB
brwl-PA
brwl-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    9568890..9573572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164859.2 → NP_723469.1  brickwall, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723469.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T091, Q9VLA6
    Related
    FBpp0079432
    Conserved Domains (2) summary
    smart00595
    Location:60 → 145
    MADF; subfamily of SANT domain
    pfam02944
    Location:356 → 389
    BESS; BESS motif

  2. NM_135454.5 → NP_609298.1  brickwall, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609298.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T091, Q9VLA6
    Related
    FBpp0079433
    Conserved Domains (2) summary
    smart00595
    Location:60 → 145
    MADF; subfamily of SANT domain
    pfam02944
    Location:356 → 389
    BESS; BESS motif
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T091 Q8T091
Q9VLA6 Q9VLA6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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