Dh31 Diuretic hormone 31 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dh31provided by FlyBase
Official Full Name: Diuretic hormone 31provided by FlyBase
Primary source: FLYBASE:FBgn0032048
Locus tag: Dmel_CG13094
See related: AllianceGenome:FB:FBgn0032048
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Posey114; anon-WO02059370.45; CG13094; DH 31; DH-II; dh31; DH31; DH[31]; DH[[31]; Dh[[31]]; DH[[31]]; Dmel\CG13094; Drm-DH[[31]]; drome-DH31; Drome-DH[[31]]
Summary: Enables G protein-coupled receptor binding activity and diuretic hormone activity. Involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; body fluid secretion; and positive regulation of circadian sleep/wake cycle, wakefulness. Located in cytoplasm and extracellular space. Is expressed in adult brain; embryonic abdominal segment 5; larval A27e neurons; midgut; and ventral midline of embryo. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 29D1-29D3; 2-33 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (8491868..8506845, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (8491868..8506845, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Female reproductive dormancy in Drosophila is regulated by DH31-producing neurons projecting into the corpus allatum.
Title: Female reproductive dormancy in Drosophila is regulated by DH31-producing neurons projecting into the corpus allatum.
The authors identify a novel role for DH31 in regulating the circadian rhythms of locomotor activity.
Title: Neuropeptides PDF and DH31 hierarchically regulate free-running rhythmicity in Drosophila circadian locomotor activity.
Midgut-preferential RNA knockdown of the peptide hormones AstA or Dh31 respectively results in decreased or increased adult lifespan. This effect on longevity is apparently correlated with the midgut senescence phenotypes as a result of direct hormone action through both hormone receptors expressed in the enteroblasts or other midgut cell types
Title: Drosophila Peptide Hormones Allatostatin A and Diuretic Hormone 31 Exhibiting Complementary Gradient Distribution in Posterior Midgut Antagonistically Regulate Midgut Senescence and Adult Lifespan.
Both ROS and TRPA1 are required in a subset of anterior enteroendocrine cells for the release of the DH31 neuropeptide which activates its receptor in the neighboring visceral muscles. The resulting contractions of the visceral muscles favors quick expulsion of opportunistic bacteria, limiting their presence in the gut.
Title: The DH31/CGRP enteroendocrine peptide triggers intestinal contractions favoring the elimination of opportunistic bacteria.
Va-A1 neurons terminally differentiate into DH31/AstA-expressing neurons (neuropeptidergic fate I) by virtue of Ubx activity, and Va-A2-A4 neurons terminally differentiate into Capa-expressing neurons
Title: Segmentally homologous neurons acquire two different terminal neuropeptidergic fates in the Drosophila nervous system.
Body temperature rhythm (BTR) is fundamental for the maintenance of functions essential for homeostasis, such as generating metabolic energy and sleep. One major unsolved question is how body temperature decreases dramatically during the night. Previously, we demonstrated that a BTR-like mechanism, referred to as temperature preference rhythm (TPR), exists in Drosophila Here, we demonstrate that the diuretic hormone 31 (D
Title: Drosophila DH31 Neuropeptide and PDF Receptor Regulate Night-Onset Temperature Preference.
the Midgut Junction DH31 expressing cells are necessary and sufficient for motility and that the peptide hormone DH31 is required for peristalsis in the junction region of the midgut.
Title: Peristalsis in the junction region of the Drosophila larval midgut is modulated by DH31 expressing enteroendocrine cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables diuretic hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables diuretic hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables diuretic hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in body fluid secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in body fluid secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect courtship behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of circadian sleep/wake cycle, wakefulness	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to temperature stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISM Inferred from Sequence Model more info