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dachs dachs [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34179, updated on 2-Nov-2024

Summary

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Official Symbol
dachsprovided by FlyBase
Official Full Name
dachsprovided by FlyBase
Primary source
FLYBASE:FBgn0262029
Locus tag
Dmel_CG42840
See related
AllianceGenome:FB:FBgn0262029
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
29C3-D1; 29CD; AAF52683; anon-EST:Liang-1.78; CG10595; CG13087; CG31610; CG42840; clone 1.78; d; D; Dachs; Dh; Dmel\CG42840; DmMyo20; Ds; l(2)c00146; Myo29D; Myo3A
Old locus tag
Dmel_CG10595; Dmel_CG13087
Summary
Enables actin filament binding activity and molecular adaptor activity. Involved in several processes, including establishment of planar polarity; imaginal disc-derived wing vein morphogenesis; and negative regulation of hippo signaling. Located in apicolateral plasma membrane and cytosol. Is expressed in several structures, including dorsal epidermis primordium; embryonic dorsal epidermis; embryonic head epidermis; gut section; and head epidermis primordium. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See dachs in Genome Data Viewer
Location:
29D1-29D1; 2-33 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8466817..8488671)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8466817..8488671)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene 1-Acylglycerol-3-phosphate O-acyltransferase 2 Neighboring gene piragua Neighboring gene transfer RNA:Aspartic acid-GTC 1-2 Neighboring gene transfer RNA:Aspartic acid-GTC 1-3 Neighboring gene Chemosensory protein A 29a Neighboring gene long non-coding RNA:CR43604 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pattern as a function of cell number and cell size on the second-leg basitarsus ofDrosophila. Held LI Jr. Wilehm Roux Arch Dev Biol, 1979 Jun. PMID 28304925
  2. Drosophila myosin-XX functions as an actin-binding protein to facilitate the interaction between Zyx102 and actin. Cao Y, et al. Biochemistry, 2014 Jan 21. PMID 24393048
  3. A global pattern of mechanical stress polarizes cell divisions and cell shape in the growing Drosophila wing disc. Legoff L, et al. Development, 2013 Oct. PMID 24046320
  4. Prickle isoforms control the direction of tissue polarity by microtubule independent and dependent mechanisms. Sharp KA, et al. Biol Open, 2016 Feb 10. PMID 26863941, Free PMC Article
  5. The Dachsous/Fat/Four-Jointed Pathway Directs the Uniform Axial Orientation of Epithelial Cells in the Drosophila Abdomen. Mangione F, et al. Cell Rep, 2018 Dec 4. PMID 30517870

See all (148) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Boundaries of Ft and Ds expression result in subcellular asymmetries in protein distribution that are transmitted to neighboring cells, and asymmetric Ds localization results in a corresponding asymmetric distribution of the myosin Dachs.
    Title: Planar polarity specification through asymmetric subcellular localization of Fat and Dachsous.
  2. role in signaling interactions that regulate growth and patterning of the proximal wing; Dachs is a candidate downstream effector of a Fat signaling pathway
    Title: Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling.
  3. Dachs is a crucial downstream component of a Fat signaling pathway that influences growth, affinity and gene expression during development.
    Title: Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables cytoskeletal motor activity TAS
Traceable Author Statement
more info
 PubMed 
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of ommatidial planar polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of planar polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived wing vein morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in leg disc development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of hippo signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of imaginal disc growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization involved in establishment of planar polarity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in wing disc development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apicolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dachs
Names
CG42840-PD
CG42840-PE
dachs-PD
dachs-PE
lethal (2) c00146
myosin 29D
unconventional myosin 29D

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8466817..8488671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001201801.2 → NP_001188730.1  dachs, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188730.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRE4, Q95VU9
    Conserved Domains (2) summary
    smart00242
    Location:476 → 1217
    MYSc; Myosin. Large ATPases
    cd14881
    Location:488 → 1206
    MYSc_Myo20; class XX myosin, motor domain

  2. NM_001201800.1 → NP_001188729.1  dachs, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188729.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5RJR1, Q95VU9
    Conserved Domains (2) summary
    smart00242
    Location:294 → 1035
    MYSc; Myosin. Large ATPases
    cd14881
    Location:306 → 1024
    MYSc_Myo20; class XX myosin, motor domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B5RJR1 B5RJR1
M9MRE4 M9MRE4
Q8T6L8 Q8T6L8
Q8T6L9 Q8T6L9
Q95VU9 Q95VU9
Q960K4 Q960K4

Gene LinkOut

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