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Dad1 Defender against apoptotic cell death 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34159, updated on 4-Jul-2024

Summary

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Official Symbol
Dad1provided by FlyBase
Official Full Name
Defender against apoptotic cell death 1provided by FlyBase
Primary source
FLYBASE:FBgn0263852
Locus tag
Dmel_CG13393
See related
AllianceGenome:FB:FBgn0263852
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE23864; CG13393; dDad1; Dmel\CG13393; l(2)k12914; OST
Summary
Involved in protein N-linked glycosylation. Is integral component of endoplasmic reticulum membrane. Is expressed in adult head and adult heart. Orthologous to human DAD1 (defender against cell death 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Dad1 in Genome Data Viewer
Location:
29B4-29B4; 2-31 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8383612..8384137, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8383612..8384137, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Alanyl-tRNA synthetase Neighboring gene uncharacterized protein Neighboring gene Reduction in Cnn dots 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene small nuclear RNA U6atac

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Endoplasmic reticulum proteins Meigo and Gp93 govern dendrite targeting by regulating Toll-6 localization. Kamemura K, et al. Dev Biol, 2022 Apr. PMID 35134382
  2. The defender against apoptotic cell death 1 gene is required for tissue growth and efficient N-glycosylation in Drosophila melanogaster. Zhang Y, et al. Dev Biol, 2016 Dec 1. PMID 27693235
  3. A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway. Arsham AM, et al. PLoS One, 2009 Jun 29. PMID 19562034, Free PMC Article
  4. RIP-seq analysis of eukaryotic Sm proteins identifies three major categories of Sm-containing ribonucleoproteins. Lu Z, et al. Genome Biol, 2014 Jan 7. PMID 24393626, Free PMC Article
  5. Phenotype-based clustering of glycosylation-related genes by RNAi-mediated gene silencing. Yamamoto-Hino M, et al. Genes Cells, 2015 Jun. PMID 25940448, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. loss of dDad1 function activates JNK signaling and blocking the JNK pathway in dDad1 knock-down tissues suppresses cell apoptosis and partially restores organ size.
    Title: The defender against apoptotic cell death 1 gene is required for tissue growth and efficient N-glycosylation in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of oligosaccharyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of oligosaccharyltransferase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
defender against apoptotic cell death 1
Names
CG13393-PA
Dad1-PA
lethal (2) k12914

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8383612..8384137 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135378.4 → NP_609222.1  defender against apoptotic cell death 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609222.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A1B2AKP8, Q9VLM5
    Related
    FBpp0079324
    Conserved Domains (1) summary
    pfam02109
    Location:5 → 112
    DAD; DAD family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VLM5.1 Q9VLM5

Gene LinkOut

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