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CG12375 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34106, updated on 10-May-2024

Summary

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Official Symbol
CG12375provided by FlyBase
Primary source
FLYBASE:FBgn0031987
Locus tag
Dmel_CG12375
See related
AllianceGenome:FB:FBgn0031987
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG12375
Summary
Predicted to enable endoribonuclease activity and single-stranded RNA binding activity. Predicted to be active in mitochondrial matrix. Is expressed in embryonic/larval midgut and organism. Orthologous to human LACTB2 (lactamase beta 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See CG12375 in Genome Data Viewer
Location:
28E7-28E7; 2-30 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8125668..8126890, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8125668..8126890, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Basigin Neighboring gene monensin sensitivity 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Phosphatidic Acid Phospholipase A1 Neighboring gene mir-4984 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Non-random genomic integration - an intrinsic property of retrogenes in Drosophila? Metta M, et al. BMC Evol Biol, 2010 Apr 28. PMID 20426838, Free PMC Article
  2. Genes Relocated Between Drosophila Chromosome Arms Evolve Under Relaxed Selective Constraints Relative to Non-Relocated Genes. Hart MLI, et al. J Mol Evol, 2018 Jul. PMID 29926120
  3. Development of a Clickable Probe for Profiling of Protein Glutathionylation in the Central Cellular Metabolism of E. coli and Drosophila. Feng S, et al. Chem Biol, 2015 Nov 19. PMID 26526100
  4. Cold acclimation wholly reorganizes the Drosophila melanogaster transcriptome and metabolome. MacMillan HA, et al. Sci Rep, 2016 Jun 30. PMID 27357258, Free PMC Article
  5. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG12375-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8125668..8126890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135339.4 → NP_609183.1  uncharacterized protein Dmel_CG12375 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609183.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MR51, Q9VLS9
    Related
    FBpp0079258
    Conserved Domains (2) summary
    COG0491
    Location:25 → 240
    GloB; Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II [General function prediction only]
    cd07722
    Location:13 → 202
    LACTB2-like_MBL-fold; uncharacterized subgroup which includes human lactamase beta 2 and related proteins; MBL-fold metallo hydrolase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VLS9.1 Q9VLS9

Gene LinkOut

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