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ZDHHC21 zinc finger DHHC-type palmitoyltransferase 21 [ Homo sapiens (human) ]

Gene ID: 340481, updated on 5-Mar-2024

Summary

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Official Symbol
ZDHHC21provided by HGNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 21provided by HGNC
Primary source
HGNC:HGNC:20750
See related
Ensembl:ENSG00000175893 MIM:614605; AllianceGenome:HGNC:20750
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DNZ1; DHHC21; DHHC-21; HSPC097
Summary
Enables palmitoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation. Located in Golgi apparatus and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 3.1), skin (RPKM 2.5) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
9p22.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (14588797..14693432, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (14598473..14703138, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (14611069..14693430, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene nuclear factor I B Neighboring gene uncharacterized LOC124902121 Neighboring gene uncharacterized LOC124902120 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:14547038-14547640 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:14597299-14597830 Neighboring gene cell division cycle associated 4 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19775 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19776 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:14693435-14693935 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:14721879-14722818 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:14722819-14723756 Neighboring gene uncharacterized LOC105375979 Neighboring gene cerberus 1, DAN family BMP antagonist Neighboring gene FRAS1 related extracellular matrix 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The Protein Acyl Transferase ZDHHC21 Modulates α1 Adrenergic Receptor Function and Regulates Hemodynamics. Marin EP, et al. Arterioscler Thromb Vasc Biol, 2016 Feb. PMID 26715683, Free PMC Article
  2. Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome. Beard RS Jr, et al. Nat Commun, 2016 Sep 22. PMID 27653213, Free PMC Article
  3. Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases. Marin EP, et al. Circ Res, 2012 May 11. PMID 22496122, Free PMC Article
  4. Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03). Le Clerc S, et al. J Infect Dis, 2009 Oct 15. PMID 19754311
  5. DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors. Pedram A, et al. Mol Biol Cell, 2012 Jan. PMID 22031296, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The palmitoyltransferase ZDHHC21 regulates oxidative phosphorylation to induce differentiation block and stemness in AML.
    Title: The palmitoyltransferase ZDHHC21 regulates oxidative phosphorylation to induce differentiation block and stemness in AML.
  2. We show that knockdown of ZDHHC21 leads to reduced levels of platelet endothelial cell adhesion molecule-1 at the cell surface.
    Title: Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases.
  3. the DHHC-7 and -21 proteins are novel targets to selectively inhibit membrane sex steroid receptor localization and function
    Title: DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog
Novel associations for hypothyroidism include known autoimmune risk loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • 9130404H11Rik

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables palmitoyltransferase activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-cysteine S-palmitoyltransferase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in adrenergic receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in hair follicle development IEA
Inferred from Electronic Annotation
more info
  
involved_in nitric oxide metabolic process TAS
Traceable Author Statement
more info
  
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-L-cysteine S-palmitoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein palmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of establishment of endothelial barrier ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of leukocyte adhesion to arterial endothelial cell ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of vascular associated smooth muscle contraction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sebaceous gland development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
palmitoyltransferase ZDHHC21
Names
DHHC domain-containing cysteine-rich protein 21
zinc finger DHHC-type containing 21
zinc finger, DHHC domain containing 21
NP_001341047.1
NP_001341048.1
NP_001341049.1
NP_001341050.1
NP_001341051.1
NP_001341052.1
NP_001341053.1
NP_001341054.1
NP_001341055.1
NP_001341056.1
NP_001341057.1
NP_001341058.1
NP_001341059.1
NP_848661.1
XP_016870172.1
XP_047279289.1
XP_047279290.1
XP_054218875.1
XP_054218876.1
XP_054218877.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001354118.2 → NP_001341047.1  palmitoyltransferase ZDHHC21 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL390732
    Consensus CDS
    CCDS6475.1
    UniProtKB/Swiss-Prot
    A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
    Conserved Domains (1) summary
    pfam01529
    Location:92 → 217
    DHHC; DHHC palmitoyltransferase

  2. NM_001354119.2 → NP_001341048.1  palmitoyltransferase ZDHHC21 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL390732
    Consensus CDS
    CCDS6475.1
    UniProtKB/Swiss-Prot
    A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
    Conserved Domains (1) summary
    pfam01529
    Location:92 → 217
    DHHC; DHHC palmitoyltransferase

  3. NM_001354120.2 → NP_001341049.1  palmitoyltransferase ZDHHC21 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL390732
    Consensus CDS
    CCDS6475.1
    UniProtKB/Swiss-Prot
    A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
    Conserved Domains (1) summary
    pfam01529
    Location:92 → 217
    DHHC; DHHC palmitoyltransferase

  4. NM_001354121.2 → NP_001341050.1  palmitoyltransferase ZDHHC21 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL390732
    Consensus CDS
    CCDS6475.1
    UniProtKB/Swiss-Prot
    A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
    Conserved Domains (1) summary
    pfam01529
    Location:92 → 217
    DHHC; DHHC palmitoyltransferase

  5. NM_001354122.2 → NP_001341051.1  palmitoyltransferase ZDHHC21 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL390732
    Consensus CDS
    CCDS6475.1
    UniProtKB/Swiss-Prot
    A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
    Conserved Domains (1) summary
    pfam01529
    Location:92 → 217
    DHHC; DHHC palmitoyltransferase

  6. NM_001354123.2 → NP_001341052.1  palmitoyltransferase ZDHHC21 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL390732
    Consensus CDS
    CCDS6475.1
    UniProtKB/Swiss-Prot
    A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
    Conserved Domains (1) summary
    pfam01529
    Location:92 → 217
    DHHC; DHHC palmitoyltransferase

  7. NM_001354124.2 → NP_001341053.1  palmitoyltransferase ZDHHC21 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL390732
    Consensus CDS
    CCDS6475.1
    UniProtKB/Swiss-Prot
    A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
    Conserved Domains (1) summary
    pfam01529
    Location:92 → 217
    DHHC; DHHC palmitoyltransferase

  8. NM_001354125.2 → NP_001341054.1  palmitoyltransferase ZDHHC21 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL390732
    Conserved Domains (1) summary
    pfam01529
    Location:63 → 188
    zf-DHHC; DHHC palmitoyltransferase

  9. NM_001354126.2 → NP_001341055.1  palmitoyltransferase ZDHHC21 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL390732
    Conserved Domains (1) summary
    pfam01529
    Location:63 → 188
    zf-DHHC; DHHC palmitoyltransferase

  10. NM_001354127.2 → NP_001341056.1  palmitoyltransferase ZDHHC21 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL390732
    Conserved Domains (1) summary
    pfam01529
    Location:2 → 120
    DHHC; DHHC palmitoyltransferase

  11. NM_001354128.2 → NP_001341057.1  palmitoyltransferase ZDHHC21 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL390732
    Conserved Domains (1) summary
    pfam01529
    Location:2 → 120
    DHHC; DHHC palmitoyltransferase

  12. NM_001354129.2 → NP_001341058.1  palmitoyltransferase ZDHHC21 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL390732
    Conserved Domains (1) summary
    pfam01529
    Location:2 → 120
    DHHC; DHHC palmitoyltransferase

  13. NM_001354130.2 → NP_001341059.1  palmitoyltransferase ZDHHC21 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL390732
    Conserved Domains (1) summary
    pfam01529
    Location:2 → 120
    DHHC; DHHC palmitoyltransferase

  14. NM_178566.6 → NP_848661.1  palmitoyltransferase ZDHHC21 isoform 1

    See identical proteins and their annotated locations for NP_848661.1

    Status: VALIDATED

    Source sequence(s)
    AK292960, AL390732
    Consensus CDS
    CCDS6475.1
    UniProtKB/Swiss-Prot
    A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
    Related
    ENSP00000370303.3, ENST00000380916.9
    Conserved Domains (1) summary
    pfam01529
    Location:92 → 217
    DHHC; DHHC palmitoyltransferase

RNA

  1. NR_148714.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL390732

  2. NR_148715.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL390732

  3. NR_148716.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL390732

  4. NR_148717.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL390732

  5. NR_148718.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL390732

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    14588797..14693432 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014683.2 → XP_016870172.1  palmitoyltransferase ZDHHC21 isoform X1

    UniProtKB/Swiss-Prot
    A8KA95, D3DRI7, Q5VWG1, Q8IVQ6
    Conserved Domains (1) summary
    pfam01529
    Location:92 → 217
    DHHC; DHHC palmitoyltransferase

  2. XM_047423334.1 → XP_047279290.1  palmitoyltransferase ZDHHC21 isoform X1

    UniProtKB/Swiss-Prot
    A8KA95, D3DRI7, Q5VWG1, Q8IVQ6

  3. XM_047423333.1 → XP_047279289.1  palmitoyltransferase ZDHHC21 isoform X1

    UniProtKB/Swiss-Prot
    A8KA95, D3DRI7, Q5VWG1, Q8IVQ6

RNA

  1. XR_001746284.2 RNA Sequence

  2. XR_001746285.2 RNA Sequence

  3. XR_007061286.1 RNA Sequence

  4. XR_007061285.1 RNA Sequence

  5. XR_007061287.1 RNA Sequence

  6. XR_007061288.1 RNA Sequence

  7. XR_002956779.2 RNA Sequence

  8. XR_007061290.1 RNA Sequence

  9. XR_007061289.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    14598473..14703138 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362900.1 → XP_054218875.1  palmitoyltransferase ZDHHC21 isoform X1

    UniProtKB/Swiss-Prot
    A8KA95, D3DRI7, Q5VWG1, Q8IVQ6

  2. XM_054362902.1 → XP_054218877.1  palmitoyltransferase ZDHHC21 isoform X1

    UniProtKB/Swiss-Prot
    A8KA95, D3DRI7, Q5VWG1, Q8IVQ6

  3. XM_054362901.1 → XP_054218876.1  palmitoyltransferase ZDHHC21 isoform X1

    UniProtKB/Swiss-Prot
    A8KA95, D3DRI7, Q5VWG1, Q8IVQ6

RNA

  1. XR_008488005.1 RNA Sequence

  2. XR_008488004.1 RNA Sequence

  3. XR_008488001.1 RNA Sequence

  4. XR_008488003.1 RNA Sequence

  5. XR_008488002.1 RNA Sequence

  6. XR_008488007.1 RNA Sequence

  7. XR_008488006.1 RNA Sequence

  8. XR_008488008.1 RNA Sequence

  9. XR_008488009.1 RNA Sequence

  10. XR_008488011.1 RNA Sequence

  11. XR_008488010.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IVQ6.1 GenPept UniProtKB/Swiss-Prot:Q8IVQ6

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