U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

WDR97 WD repeat domain 97 [ Homo sapiens (human) ]

Gene ID: 340390, updated on 16-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
WDR97provided by HGNC
Official Full Name
WD repeat domain 97provided by HGNC
Primary source
HGNC:HGNC:26959
See related
Ensembl:ENSG00000179698 AllianceGenome:HGNC:26959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA1875
Summary
The function and protein-coding potential of this gene is unknown. The exon combination is based on AB058778.1 for which two possible open reading frames can be predicted (with start codons at nucleotide 26 or 2614). The position of the first ORF stop codon is consistent with a prediction of nonsense-mediated decay. Given the observation of the first ORF and its length, a predicted translation of the second ORF is inconsistent with the translation leaky scanning theory. Therefore, this gene is represented as a non-protein-coding transcript. [provided by RefSeq, Oct 2008]
Expression
Biased expression in testis (RPKM 5.3), brain (RPKM 0.6) and 9 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
8q24.3
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144107739..144118328)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (145268535..145279125)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145162642..145173231)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene SHANK associated RH domain interactor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19656 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28089 Neighboring gene Sharpr-MPRA regulatory region 2030 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145163585-145164115 Neighboring gene MAF1 homolog, negative regulator of RNA polymerase III Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28090 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19659 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19660 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19661 Neighboring gene HGH1 homolog Neighboring gene testis specific serine kinase 5, pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2001 Apr 27. PMID 11347906
  2. A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling. Kumar P, et al. J Proteome Res, 2017 Aug 4. PMID 28675297, Free PMC Article
  3. A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

General protein information

Go to the top of the page Help
Preferred Names
WD repeat-containing protein 97

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316309.2 → NP_001303238.1  WD repeat-containing protein 97

    Status: VALIDATED

    Source sequence(s)
    AC104592
    Consensus CDS
    CCDS83334.1
    UniProtKB/Swiss-Prot
    A6NE52, Q96JF2
    Related
    ENSP00000320648.8, ENST00000323662.9
    Conserved Domains (3) summary
    COG2319
    Location:206 → 363
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:252 → 288
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:200 → 370
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    144107739..144118328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421748.1 → XP_047277704.1  WD repeat-containing protein 97 isoform X3

  2. XM_047421746.1 → XP_047277702.1  WD repeat-containing protein 97 isoform X1

  3. XM_047421747.1 → XP_047277703.1  WD repeat-containing protein 97 isoform X2

  4. XM_047421750.1 → XP_047277706.1  WD repeat-containing protein 97 isoform X5

  5. XM_047421751.1 → XP_047277707.1  WD repeat-containing protein 97 isoform X6

  6. XM_047421749.1 → XP_047277705.1  WD repeat-containing protein 97 isoform X4

  7. XM_047421753.1 → XP_047277709.1  WD repeat-containing protein 97 isoform X8

  8. XM_047421752.1 → XP_047277708.1  WD repeat-containing protein 97 isoform X7

  9. XM_047421754.1 → XP_047277710.1  WD repeat-containing protein 97 isoform X9

  10. XM_047421755.1 → XP_047277711.1  WD repeat-containing protein 97 isoform X10

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    145268535..145279125
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360417.1 → XP_054216392.1  WD repeat-containing protein 97 isoform X3

  2. XM_054360415.1 → XP_054216390.1  WD repeat-containing protein 97 isoform X1

  3. XM_054360416.1 → XP_054216391.1  WD repeat-containing protein 97 isoform X2

  4. XM_054360419.1 → XP_054216394.1  WD repeat-containing protein 97 isoform X5

  5. XM_054360420.1 → XP_054216395.1  WD repeat-containing protein 97 isoform X6

  6. XM_054360418.1 → XP_054216393.1  WD repeat-containing protein 97 isoform X4

  7. XM_054360422.1 → XP_054216397.1  WD repeat-containing protein 97 isoform X8

  8. XM_054360421.1 → XP_054216396.1  WD repeat-containing protein 97 isoform X7

  9. XM_054360423.1 → XP_054216398.1  WD repeat-containing protein 97 isoform X9

  10. XM_054360424.1 → XP_054216399.1  WD repeat-containing protein 97 isoform X10

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_032529.1: Suppressed sequence

    Description
    NM_032529.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  2. NR_024207.1: Suppressed sequence

    Description
    NR_024207.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NE52.2 GenPept UniProtKB/Swiss-Prot:A6NE52

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous