U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Wnt6 Wnt oncogene analog 6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34010, updated on 11-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
Wnt6provided by FlyBase
Official Full Name
Wnt oncogene analog 6provided by FlyBase
Primary source
FLYBASE:FBgn0031902
Locus tag
Dmel_CG4969
See related
AllianceGenome:FB:FBgn0031902
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4969; D-Wnt-6; Dmel\CG4969; Dwnt-6; DWnt-6; Dwnt6; DWnt6; wnt6
Summary
Predicted to enable cytokine activity and frizzled binding activity. Involved in canonical Wnt signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in imaginal disc; maxillary palpus; and presumptive embryonic/larval digestive system. Orthologous to human WNT6 (Wnt family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Wnt6 in Genome Data Viewer
Location:
27F1-27F2; 2-26 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7333714..7352542)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7333714..7352542)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene wingless Neighboring gene long non-coding RNA:CR45304 Neighboring gene antisense RNA:CR44063 Neighboring gene Wnt oncogene analog 10 Neighboring gene neither inactivation nor afterpotential C

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Gain of cis-regulatory activities underlies novel domains of wingless gene expression in Drosophila. Koshikawa S, et al. Proc Natl Acad Sci U S A, 2015 Jun 16. PMID 26034272, Free PMC Article
  2. Wnt gene regulation and function during maxillary palp development in Drosophila melanogaster. Holzem M, et al. Dev Biol, 2020 Jun 1. PMID 32229133
  3. Wnt6 maintains anterior escort cells as an integral component of the germline stem cell niche. Wang X, et al. Development, 2018 Feb 7. PMID 29361569, Free PMC Article
  4. Wnt6 is required for maxillary palp formation in Drosophila. Doumpas N, et al. BMC Biol, 2013 Oct 3. PMID 24090348, Free PMC Article
  5. Expression of DWnt6, DWnt10, and DFz4 during Drosophila development. Janson K, et al. Mech Dev, 2001 May. PMID 11335117

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Wnt6 regulates the homeostasis of the stem cell niche via Rac1-and Cdc42-mediated noncanonical Wnt signalling pathways in Drosophila testis.
    Title: Wnt6 regulates the homeostasis of the stem cell niche via Rac1-and Cdc42-mediated noncanonical Wnt signalling pathways in Drosophila testis.
  2. Anterior escort cells are maintained by Wnt6 ligands produced by cap cells; without Wnt6 signaling, anterior escort cells die leaving vacancies in the niche, leading to loss of germline stem cells.
    Title: Wnt6 maintains anterior escort cells as an integral component of the germline stem cell niche.
  3. Wnt6 is important for maxillary palp development in Drosophila, and phylogenetic analysis indicates that loss of Wnt6 may also have led to loss of maxillary palps on an evolutionary time scale.
    Title: Wnt6 is required for maxillary palp formation in Drosophila.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

mobile_element

  • Loc: 7343381-7350438 mobile_element_type = transposon:roo{}319

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Wnt oncogene analog 6
Names
CG4969-PB
CG4969-PC
Wnt6-PB
Wnt6-PC

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    7333714..7352542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135264.4 → NP_609108.3  Wnt oncogene analog 6, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609108.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    G2J621, Q9VM26
    Conserved Domains (1) summary
    pfam00110
    Location:41 → 419
    wnt; wnt family

  2. NM_001273259.1 → NP_001260188.1  Wnt oncogene analog 6, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260188.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G2J621, Q9VM26
    Conserved Domains (1) summary
    pfam00110
    Location:41 → 419
    wnt; wnt family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VM26 Q9VM26

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous