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LRRC66 leucine rich repeat containing 66 [ Homo sapiens (human) ]

Gene ID: 339977, updated on 11-Apr-2024

Summary

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Official Symbol
LRRC66provided by HGNC
Official Full Name
leucine rich repeat containing 66provided by HGNC
Primary source
HGNC:HGNC:34299
See related
Ensembl:ENSG00000188993 AllianceGenome:HGNC:34299
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. [provided by RefSeq, Apr 2017]
Expression
Biased expression in duodenum (RPKM 4.6), small intestine (RPKM 4.1) and 4 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
4q12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (51993652..52020363, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (55479597..55506301, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (52859818..52886529, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene defective in cullin neddylation 1 domain containing 4 Neighboring gene deoxyuridine triphosphatase pseudogene 7 Neighboring gene ribosomal protein L37a pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21552 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15421 Neighboring gene sarcoglycan beta Neighboring gene long intergenic non-protein coding RNA 2480

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes correlate with sperm motility in idiopathic infertility. Gupta N, et al. Andrologia, 2022 Oct. PMID 35768906
  2. Yeast Two-Hybrid Screening for Proteins that Interact with the Extracellular Domain of Amyloid Precursor Protein. Yu Y, et al. Neurosci Bull, 2016 Apr. PMID 26960425, Free PMC Article
  3. TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions. Banks CA, et al. Mol Cell Proteomics, 2016 Nov. PMID 27609421, Free PMC Article
  4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes correlate with sperm motility in idiopathic infertility.
    Title: Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes correlate with sperm motility in idiopathic infertility.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in long-term memory IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 66

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053164.1 RefSeqGene

    Range
    4949..31660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001024611.3 → NP_001019782.1  leucine-rich repeat-containing protein 66 precursor

    See identical proteins and their annotated locations for NP_001019782.1

    Status: REVIEWED

    Source sequence(s)
    AC093858, BU620718, CA436716, CR749811
    Consensus CDS
    CCDS43229.1
    UniProtKB/Swiss-Prot
    Q68CR7
    Related
    ENSP00000508002.1, ENST00000682860.1
    Conserved Domains (3) summary
    cd00116
    Location:60 → 255
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:88 → 110
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:171 → 231
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    51993652..52020363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047415645.1 → XP_047271601.1  leucine-rich repeat-containing protein 66 isoform X2

  2. XM_047415644.1 → XP_047271600.1  leucine-rich repeat-containing protein 66 isoform X1

  3. XM_047415646.1 → XP_047271602.1  leucine-rich repeat-containing protein 66 isoform X3

  4. XM_047415647.1 → XP_047271603.1  leucine-rich repeat-containing protein 66 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    55479597..55506301 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349929.1 → XP_054205904.1  leucine-rich repeat-containing protein 66 isoform X2

  2. XM_054349928.1 → XP_054205903.1  leucine-rich repeat-containing protein 66 isoform X1

  3. XM_054349930.1 → XP_054205905.1  leucine-rich repeat-containing protein 66 isoform X3

  4. XM_054349931.1 → XP_054205906.1  leucine-rich repeat-containing protein 66 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68CR7.1 GenPept UniProtKB/Swiss-Prot:Q68CR7

Gene LinkOut

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