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MME1 Mitochondrial Magnesium Exporter 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33987, updated on 2-Nov-2024

Summary

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Official Symbol
MME1provided by FlyBase
Official Full Name
Mitochondrial Magnesium Exporter 1provided by FlyBase
Primary source
FLYBASE:FBgn0031881
Locus tag
Dmel_CG3476
See related
AllianceGenome:FB:FBgn0031881
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3476; Dmel\CG3476; dMme1
Summary
Enables magnesium ion transmembrane transporter activity. Involved in intracellular magnesium ion homeostasis and magnesium ion export from mitochondrion. Is active in mitochondrial inner membrane. Is expressed in several structures, including adult head; anterior endoderm anlage; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm. Human ortholog(s) of this gene implicated in carnitine-acylcarnitine translocase deficiency. Orthologous to human SLC25A20 (solute carrier family 25 member 20). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See MME1 in Genome Data Viewer
Location:
27D4-27D5; 2-24 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7027526..7028959)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7027526..7028959)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene GART trifunctional enzyme Neighboring gene Pupal cuticle protein Neighboring gene uncharacterized protein Neighboring gene Rab30 Neighboring gene caper Neighboring gene milton

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel Drosophila mitochondrial carrier protein acts as a Mg(2+) exporter in fine-tuning mitochondrial Mg(2+) homeostasis. Cui Y, et al. Biochim Biophys Acta, 2016 Jan. PMID 26462626
  2. Widespread adaptive evolution of Drosophila genes with sex-biased expression. Pröschel M, et al. Genetics, 2006 Oct. PMID 16951084, Free PMC Article
  3. The histone demethylase dKDM5/LID interacts with the SIN3 histone deacetylase complex and shares functional similarities with SIN3. Gajan A, et al. Epigenetics Chromatin, 2016. PMID 26848313, Free PMC Article
  4. Filtering of Data-Driven Gene Regulatory Networks Using Drosophila melanogaster as a Case Study. Cuesta-Astroz Y, et al. Front Genet, 2021. PMID 34394179, Free PMC Article
  5. Loss of the SIN3 transcriptional corepressor results in aberrant mitochondrial function. Barnes VL, et al. BMC Biochem, 2010 Jul 9. PMID 20618965, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acyl carnitine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in carnitine transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular magnesium ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular magnesium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in magnesium ion export from mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in magnesium ion export from mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial inner membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
mitochondrial magnesium exporter 1
Names
CG3476-PA
MME1-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    7027526..7028959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135249.3 → NP_609093.1  mitochondrial magnesium exporter 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609093.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VM51
    UniProtKB/TrEMBL
    A0APZ9, C0MKK1
    Related
    FBpp0079017
    Conserved Domains (1) summary
    pfam00153
    Location:10 → 107
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VM51.1 Q9VM51

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