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Tsp Thrombospondin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33941, updated on 28-Oct-2024

Summary

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Official Symbol
Tspprovided by FlyBase
Official Full Name
Thrombospondinprovided by FlyBase
Primary source
FLYBASE:FBgn0031850
Locus tag
Dmel_CG11326
See related
AllianceGenome:FB:FBgn0031850
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11326; CT31613; D-TSP; Dmel\CG11326; DTSP; SP295; tsp; TSP
Summary
Enables heparin binding activity. Involved in cell adhesion mediated by integrin and muscle attachment. Located in collagen-containing extracellular matrix and muscle tendon junction. Part of protein-containing complex. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval hypodermal muscle cell; endoderm anlage; epidermis; and head epidermis primordium. Human ortholog(s) of this gene implicated in carpal tunnel syndrome 2; multiple epiphyseal dysplasia 1; osteochondrodysplasia; and pseudoachondroplasia. Orthologous to several human genes including THBS3 (thrombospondin 3). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
all
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Genomic context

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See Tsp in Genome Data Viewer
Location:
26F7-27A1; 2-22 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6686791..6709086, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6686791..6709086, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Na[+]/H[+] hydrogen exchanger 3 Neighboring gene uncharacterized protein Neighboring gene Adipokinetic hormone receptor Neighboring gene Apoptosis antagonizing transcription factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular evolution of the Thrombospondin superfamily. Tucker RP, et al. Semin Cell Dev Biol, 2024 Mar 1. PMID 37202276
  2. Characterisation of Drosophila thrombospondin defines an early origin of pentameric thrombospondins. Adams JC, et al. J Mol Biol, 2003 Apr 25. PMID 12691755
  3. Loss of thrombospondin reveals a possible role for the extracellular matrix in chordotonal cap cell elongation. Greenblatt Ben-El RT, et al. Int J Dev Biol, 2017. PMID 28621428
  4. A thrombospondin homologue in Drosophila melanogaster: cDNA and protein structure. Adolph KW. Gene, 2001 May 16. PMID 11376949
  5. Thrombospondin expression in myofibers stabilizes muscle membranes. Vanhoutte D, et al. Elife, 2016 Sep 26. PMID 27669143, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the conserved transmembrane Drosophila proteoglycan Kon-tiki (Kon, also known as Perdido) interacts with the alphaPS2betaPS integrin (alphaPS2 is encoded by inflated and betaPS by myospheroid) to mediate muscle-tendon adhesion.
    Title: Kon-tiki enhances PS2 integrin adhesion and localizes its ligand, Thrombospondin, in the myotendinous junction.
  2. thrombospondin may have a role with extracellular matrix in chordotonal cap cell elongation in Drosophila
    Title: Loss of thrombospondin reveals a possible role for the extracellular matrix in chordotonal cap cell elongation.
  3. Thrombospondin-mediated adhesion is essential for the formation of the myotendinous junction in Drosophila.
    Title: Thrombospondin-mediated adhesion is essential for the formation of the myotendinous junction in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables heparin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion mediated by integrin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle attachment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in muscle tendon junction IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
thrombospondin
Names
CG11326-PA
CG11326-PC
CG11326-PD
CG11326-PE
CG11326-PF
CG11326-PG
CG11326-PH
Tsp-PA
Tsp-PC
Tsp-PD
Tsp-PE
Tsp-PF
Tsp-PG
Tsp-PH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6686791..6709086 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144330.2 → NP_001137802.1  thrombospondin, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137802.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q968S4, Q9VM97
    Conserved Domains (9) summary
    smart00179
    Location:343 → 377
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:421 → 457
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00001
    Location:714 → 751
    TSP3; TSP3 repeat_long [structural motif]
    sd00002
    Location:656 → 690
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:563 → 595
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam02412
    Location:656 → 690
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:841 → 1038
    TSP_C; Thrombospondin C-terminal region
    pfam07645
    Location:477 → 513
    EGF_CA; Calcium-binding EGF domain
    cd16081
    Location:245 → 286
    TSPcc_insect; Coiled coil region of thrombospondin in protostomes

  2. NM_078771.3 → NP_523495.2  thrombospondin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523495.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q968S4, Q9VM97
    Related
    FBpp0078941
    Conserved Domains (9) summary
    smart00179
    Location:343 → 377
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:421 → 457
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00001
    Location:714 → 751
    TSP3; TSP3 repeat_long [structural motif]
    sd00002
    Location:656 → 690
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:563 → 595
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam02412
    Location:656 → 690
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:841 → 1038
    TSP_C; Thrombospondin C-terminal region
    pfam07645
    Location:477 → 513
    EGF_CA; Calcium-binding EGF domain
    cd16081
    Location:245 → 286
    TSPcc_insect; Coiled coil region of thrombospondin in protostomes

  3. NM_001144331.2 → NP_001137803.1  thrombospondin, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137803.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z030
    Conserved Domains (7) summary
    cd00054
    Location:12 → 48
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00001
    Location:223 → 245
    TSP3; TSP3 repeat_short [structural motif]
    sd00002
    Location:247 → 281
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:154 → 186
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam02412
    Location:247 → 281
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:432 → 629
    TSP_C; Thrombospondin C-terminal region
    pfam07645
    Location:68 → 104
    EGF_CA; Calcium-binding EGF domain

  4. NM_001273219.1 → NP_001260148.1  thrombospondin, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260148.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z030
    Conserved Domains (7) summary
    cd00054
    Location:12 → 48
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00001
    Location:223 → 245
    TSP3; TSP3 repeat_short [structural motif]
    sd00002
    Location:247 → 281
    TSP3; TSP3 repeat_long [structural motif]
    sd00003
    Location:154 → 186
    TSP3_1C; TSP3 repeat_1C [structural motif]
    pfam02412
    Location:247 → 281
    TSP_3; Thrombospondin type 3 repeat
    pfam05735
    Location:432 → 629
    TSP_C; Thrombospondin C-terminal region
    pfam07645
    Location:68 → 104
    EGF_CA; Calcium-binding EGF domain

  5. NM_164703.2 → NP_723204.1  thrombospondin, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723204.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0I9, Q9U3W8
    Related
    FBpp0078940
    Conserved Domains (2) summary
    smart00179
    Location:343 → 377
    EGF_CA; Calcium-binding EGF-like domain
    cd16081
    Location:245 → 286
    TSPcc_insect; Coiled coil region of thrombospondin in protostomes

  6. NM_164702.2 → NP_723203.1  thrombospondin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723203.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0I9, Q9U3W8
    Related
    FBpp0078942
    Conserved Domains (2) summary
    smart00179
    Location:343 → 377
    EGF_CA; Calcium-binding EGF-like domain
    cd16081
    Location:245 → 286
    TSPcc_insect; Coiled coil region of thrombospondin in protostomes

  7. NM_164704.2 → NP_723205.1  thrombospondin, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723205.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0I9, Q9U3W8
    Related
    FBpp0078943
    Conserved Domains (2) summary
    smart00179
    Location:343 → 377
    EGF_CA; Calcium-binding EGF-like domain
    cd16081
    Location:245 → 286
    TSPcc_insect; Coiled coil region of thrombospondin in protostomes
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7Z030 B7Z030
Q8T0I9 Q8T0I9
Q968S4 Q968S4
Q9U3W8 Q9U3W8
Q9VM97 Q9VM97

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