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ZNF260 zinc finger protein 260 [ Homo sapiens (human) ]

Gene ID: 339324, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF260provided by HGNC
Official Full Name
zinc finger protein 260provided by HGNC
Primary source
HGNC:HGNC:13499
See related
Ensembl:ENSG00000254004 MIM:613749; AllianceGenome:HGNC:13499
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PEX1; OZRF1; ZFP260
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 5.3), endometrium (RPKM 4.0) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
19q13.12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36510687..36528271, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (39185915..39203539, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37001589..37019173, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36980447-36981332 Neighboring gene ZNF566 antisense RNA 1 Neighboring gene CTBP2 pseudogene 7 Neighboring gene H3K27ac hESC enhancers GRCh37_chr19:37018470-37019180 and GRCh37_chr19:37019181-37019889 Neighboring gene zinc finger protein 529 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14527 Neighboring gene ZNF529 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10549 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14529 Neighboring gene zinc finger protein 382

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The zinc finger-only protein Zfp260 is a novel cardiac regulator and a nuclear effector of alpha1-adrenergic signaling. Debrus S, et al. Mol Cell Biol, 2005 Oct. PMID 16166646, Free PMC Article
  2. Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. Robertson NG, et al. Genomics, 1994 Sep 1. PMID 7829101
  3. N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cheng Y, et al. Cancer Cell, 2021 Jul 12. PMID 34048709, Free PMC Article
  4. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Luo J, et al. Cell, 2009 May 29. PMID 19490893, Free PMC Article
  5. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zfp260 is a novel transcriptional regulator in normal and pathological heart development and a nuclear effector of alpha1-adrenergic signaling
    Title: The zinc finger-only protein Zfp260 is a novel cardiac regulator and a nuclear effector of alpha1-adrenergic signaling.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 260
Names
zfp-260

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012756.3 → NP_001012774.1  zinc finger protein 260

    See identical proteins and their annotated locations for NP_001012774.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All variants (1-4) encode the same protein.
    Source sequence(s)
    AC092295, BC042676, DB283305
    Consensus CDS
    CCDS33003.1
    UniProtKB/Swiss-Prot
    Q0VF43, Q3ZCT1
    Related
    ENSP00000464964.1, ENST00000592282.1
    Conserved Domains (2) summary
    COG5048
    Location:25 → 406
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:334 → 354
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001166036.2 → NP_001159508.1  zinc finger protein 260

    See identical proteins and their annotated locations for NP_001159508.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein.
    Source sequence(s)
    AC092295, BC119003, DB283305
    Consensus CDS
    CCDS33003.1
    UniProtKB/Swiss-Prot
    Q0VF43, Q3ZCT1
    Related
    ENSP00000467219.1, ENST00000588993.1
    Conserved Domains (2) summary
    COG5048
    Location:25 → 406
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:334 → 354
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001166037.2 → NP_001159509.1  zinc finger protein 260

    See identical proteins and their annotated locations for NP_001159509.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein.
    Source sequence(s)
    AC092295, AK291442
    Consensus CDS
    CCDS33003.1
    UniProtKB/Swiss-Prot
    Q0VF43, Q3ZCT1
    Related
    ENSP00000429803.1, ENST00000523638.6
    Conserved Domains (2) summary
    COG5048
    Location:25 → 406
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:334 → 354
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001166038.2 → NP_001159510.1  zinc finger protein 260

    See identical proteins and their annotated locations for NP_001159510.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein.
    Source sequence(s)
    AC092295, BQ938102, DB283305
    Consensus CDS
    CCDS33003.1
    UniProtKB/Swiss-Prot
    Q0VF43, Q3ZCT1
    Related
    ENSP00000465834.1, ENST00000593142.5
    Conserved Domains (2) summary
    COG5048
    Location:25 → 406
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:334 → 354
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_001375596.1 → NP_001362525.1  zinc finger protein 260

    Status: VALIDATED

    Source sequence(s)
    AC092295
    Consensus CDS
    CCDS33003.1
    UniProtKB/Swiss-Prot
    Q0VF43, Q3ZCT1
    Conserved Domains (2) summary
    COG5048
    Location:25 → 406
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:334 → 354
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_001375597.1 → NP_001362526.1  zinc finger protein 260

    Status: VALIDATED

    Source sequence(s)
    AC092295
    Consensus CDS
    CCDS33003.1
    UniProtKB/Swiss-Prot
    Q0VF43, Q3ZCT1
    Conserved Domains (2) summary
    COG5048
    Location:25 → 406
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:334 → 354
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. NM_001375598.1 → NP_001362527.1  zinc finger protein 260

    Status: VALIDATED

    Source sequence(s)
    AC092295
    Consensus CDS
    CCDS33003.1
    UniProtKB/Swiss-Prot
    Q0VF43, Q3ZCT1
    Conserved Domains (2) summary
    COG5048
    Location:25 → 406
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:334 → 354
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    36510687..36528271 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026741.2 → XP_016882230.1  zinc finger protein 260 isoform X1

    UniProtKB/Swiss-Prot
    Q0VF43, Q3ZCT1
    Conserved Domains (2) summary
    COG5048
    Location:25 → 406
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:334 → 354
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    39185915..39203539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320825.1 → XP_054176800.1  zinc finger protein 260 isoform X1

    UniProtKB/Swiss-Prot
    Q0VF43, Q3ZCT1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3ZCT1.3 GenPept UniProtKB/Swiss-Prot:Q3ZCT1

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