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Sec61alpha Sec61 alpha subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33905, updated on 2-Nov-2024

Summary

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Official Symbol
Sec61alphaprovided by FlyBase
Official Full Name
Sec61 alpha subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0086357
Locus tag
Dmel_CG9539
See related
AllianceGenome:FB:FBgn0086357
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
0455; anon-WO0118547.195; anon-WO0118547.277; BcDNA:LD29847; BEST:LD29847; CG9539; Dmel\CG9539; dSEC61A; dSec61alpha; DSec61alpha; E(br)165; endd2; l(2)k04917; LD29847; sec61; Sec61; Sec61-alpha; SEC61-alpha; Sec61a; sec61alpha; SEC61ALPHA
Summary
Predicted to enable protein transmembrane transporter activity; ribosome binding activity; and signal sequence binding activity. Involved in several processes, including embryonic development via the syncytial blastoderm; positive regulation of iron ion transmembrane transport; and positive regulation of viral entry into host cell. Located in fusome and rough endoplasmic reticulum. Is expressed in several structures, including adult brain cell body rind; adult gnathal ganglion; epidermis; female germline cell; and gut section. Human ortholog(s) of this gene implicated in common variable immunodeficiency; familial juvenile hyperuricemic nephropathy; and severe congenital neutropenia. Orthologous to human SEC61A1 (SEC61 translocon subunit alpha 1) and SEC61A2 (SEC61 translocon subunit alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Sec61alpha in Genome Data Viewer
Location:
26D7-26D8; 2-20 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6477182..6480575, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6477182..6480575, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene mummy Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45463 Neighboring gene Daxx-like protein Neighboring gene Kynurenine formamidase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The fusome mediates intercellular endoplasmic reticulum connectivity in Drosophila ovarian cysts. Snapp EL, et al. Mol Biol Cell, 2004 Oct. PMID 15292454, Free PMC Article
  2. Cytosol-endoplasmic reticulum interplay by Sec61alpha translocon in polyglutamine-mediated neurotoxicity in Drosophila. Kanuka H, et al. Proc Natl Acad Sci U S A, 2003 Sep 30. PMID 14504396, Free PMC Article
  3. Genome-wide RNAi screen identifies SEC61A and VCP as conserved regulators of Sindbis virus entry. Panda D, et al. Cell Rep, 2013 Dec 26. PMID 24332855, Free PMC Article
  4. Pelota controls self-renewal of germline stem cells by repressing a Bam-independent differentiation pathway. Xi R, et al. Development, 2005 Dec. PMID 16280348
  5. Sec61alpha is required for dorsal closure during Drosophila embryogenesis through its regulation of Dpp signaling. Wang X, et al. Dev Dyn, 2010 Mar. PMID 20112345, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. dorsal closure is rescued in Sec61alpha mutant embryos by an activated form of the Dpp receptor Thick veins
    Title: Sec61alpha is required for dorsal closure during Drosophila embryogenesis through its regulation of Dpp signaling.
  2. Loss-of-function experiments for DSec61alpha revealed that the translocon contributes to expanded polyglutamine-mediated neuronal toxicity
    Title: Cytosol-endoplasmic reticulum interplay by Sec61alpha translocon in polyglutamine-mediated neurotoxicity in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signal sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in head involution IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of iron ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of viral entry into host cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-translational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Sec61 translocon complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endomembrane system HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in fusome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in rough endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Sec61 alpha subunit
Names
CG9539-PA
CG9539-PB
E(br)165
Sec61alpha-PA
Sec61alpha-PB
effector for neural death and degeneration 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6477182..6480575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298745.1 → NP_001285674.1  Sec61 alpha subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285674.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F0JAP1, Q8STG9, Q9VMD1
    Conserved Domains (1) summary
    PTZ00219
    Location:1 → 469
    PTZ00219; Sec61 alpha subunit; Provisional

  2. NM_135190.5 → NP_609034.1  Sec61 alpha subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609034.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F0JAP1, Q8STG9, Q9VMD1
    Related
    FBpp0078896
    Conserved Domains (1) summary
    PTZ00219
    Location:1 → 469
    PTZ00219; Sec61 alpha subunit; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8STG9 Q8STG9

Gene LinkOut

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