RNASE10 ribonuclease A family member 10 (inactive) [Homo sapiens (human)] - Gene

Summary

Official Symbol: RNASE10provided by HGNC
Official Full Name: ribonuclease A family member 10 (inactive)provided by HGNC
Primary source: HGNC:HGNC:19275
See related: Ensembl:ENSG00000182545 AllianceGenome:HGNC:19275
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RAH1; RNASE9
Summary: Predicted to enable nucleic acid binding activity. Predicted to be involved in several processes, including heterotypic cell-cell adhesion; positive regulation of flagellated sperm motility; and regulation of fertilization. Predicted to act upstream of or within epithelial cell morphogenesis; seminiferous tubule development; and single fertilization. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: mouse all
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Genomic context

Location:: 14q11.2

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (20504233..20513884)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (14701150..14711005)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (20972392..20982043)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124078 (e-PCR)
- UniSTS:134559

L18441 (e-PCR)
- UniSTS:71348

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
NOT enables RNA nuclease activity	IKR Inferred from Key Residues more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterotypic cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of flagellated sperm motility	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of fertilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in single fertilization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inactive ribonuclease-like protein 10

Names: ribonuclease A H1; ribonuclease, RNase A family, 10 (non-active)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012975.3 → NP_001012993.1 inactive ribonuclease-like protein 10 precursor

See identical proteins and their annotated locations for NP_001012993.1

Status: VALIDATED

Source sequence(s)

AL355075

Consensus CDS

CCDS32035.1

UniProtKB/Swiss-Prot

A2RUQ3, B4DKY4, Q5GAN6

UniProtKB/TrEMBL

W0UTC4

Related

ENSP00000333358.5, ENST00000328444.6

Conserved Domains (1) summary

cd00163
Location:108 → 213

RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...
NM_001386206.3 → NP_001373135.2 inactive ribonuclease-like protein 10 precursor

Status: VALIDATED

Source sequence(s)

AL355075

Consensus CDS

CCDS32035.1

UniProtKB/Swiss-Prot

A2RUQ3, B4DKY4, Q5GAN6

UniProtKB/TrEMBL

W0UTC4

Related

ENSP00000392996.2, ENST00000430083.2

Conserved Domains (1) summary

cd00163
Location:108 → 213

RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...