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OR2AG2 olfactory receptor family 2 subfamily AG member 2 [ Homo sapiens (human) ]

Gene ID: 338755, updated on 5-Mar-2024

Summary

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Official Symbol
OR2AG2provided by HGNC
Official Full Name
olfactory receptor family 2 subfamily AG member 2provided by HGNC
Primary source
HGNC:HGNC:15143
See related
Ensembl:ENSG00000188124 AllianceGenome:HGNC:15143
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR11-76; OR2AG2P
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs
all
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Genomic context

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See OR2AG2 in Genome Data Viewer
Location:
11p15.4
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (6765626..6771976, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (6824061..6830411, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6786857..6793207, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene GTPase, very large interferon inducible pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4357 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4358 Neighboring gene GTPase, very large interferon inducible pseudogene 2 Neighboring gene olfactory receptor family 2 subfamily AG member 1 Neighboring gene olfactory receptor family 6 subfamily A member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic variations in olfactory receptor gene OR2AG2 in a large multigenerational family with asthma. Chakraborty S, et al. Sci Rep, 2019 Dec 13. PMID 31836740, Free PMC Article
  2. DEFOG: a practical scheme for deciphering families of genes. Fuchs T, et al. Genomics, 2002 Sep. PMID 12213199
  3. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic variations in olfactory receptor gene OR2AG2 in a large multigenerational family with asthma.
    Title: Genetic variations in olfactory receptor gene OR2AG2 in a large multigenerational family with asthma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
olfactory receptor 2AG2
Names
olfactory receptor OR11-76 pseudogene
olfactory receptor, family 2, subfamily AG, member 2 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004490.2 → NP_001004490.1  olfactory receptor 2AG2

    See identical proteins and their annotated locations for NP_001004490.1

    Status: VALIDATED

    Source sequence(s)
    AC087280, AC091564
    Consensus CDS
    CCDS31413.1
    UniProtKB/Swiss-Prot
    A6NM03, B9EIM0
    UniProtKB/TrEMBL
    A0A126GW54, A0A126GWC6
    Related
    ENSP00000493362.1, ENST00000641124.1
    Conserved Domains (1) summary
    cd15421
    Location:26 → 301
    7tmA_OR2T-like; olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001386053.1 → NP_001372982.1  olfactory receptor 2AG2

    Status: VALIDATED

    Source sequence(s)
    AC087280, AC091564
    Consensus CDS
    CCDS31413.1
    UniProtKB/Swiss-Prot
    A6NM03, B9EIM0
    UniProtKB/TrEMBL
    A0A126GW54, A0A126GWC6
    Related
    ENSP00000493311.1, ENST00000641169.1
    Conserved Domains (1) summary
    cd15421
    Location:26 → 301
    7tmA_OR2T-like; olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    6765626..6771976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    6824061..6830411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NM03.1 GenPept UniProtKB/Swiss-Prot:A6NM03

Gene LinkOut

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